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Evaluation of arjunolic acid against <em>Brucella melitenis</em> and <em>in vitro</em> cytotoxic study of lung adenocarcinomic cell line (A549)

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Title Statement Evaluation of arjunolic acid against <em>Brucella melitenis</em> and <em>in vitro</em> cytotoxic study of lung adenocarcinomic cell line (A549)
 
Added Entry - Uncontrolled Name Yasasve, M
Kumaran, P Muthu
Manoj, D
Kanmani, M
Ramesh, A Sai
 
Uncontrolled Index Term Adenocarcinoma; Anticancer activity; Arjuna tree; Antibacterial activity; Brucellosis; Lung cancer cell line; Tarenna asiatica; Terminalia arjuna
 
Summary, etc. Brucellosis, a neglected tropical disease of zoonotic nature, is caused by the genus <em>Brucella</em>, specifically by <em>Brucella abortus</em> and <em>B. melitensis</em> in cattle and humans, respectively. Arjunolic acid (AA) is a triterpenoid, isolated from <em>Terminalia arjuna</em> (Roxb.) Wight &amp; Arn., a medicinally important plant used to treat various diseases in the Indian system of medicine. Here, we tried to evaluate AA for its antibacterial activity on Brucella and the <em>in vitro</em> cytotoxicity assay on human lung adenocarcinomic alveolar basal epithelial cell line (A549). Also, we assessed the synergistic effect of arjunolic acid and <em>Tarenna asiatica</em> (L.) Kuntze ex K.Schum. on <em>B. melitensis</em>. AA displayed a considerable antibacterial activity [zone of inhibition (9 mm) with a minimum inhibitory concentration of 30 μg/mL] against <em>B. melitensis</em>. The rate of cell death for the cancer cells were at 100 μg/mL concentration of AA was 82% which indicates that AA shows significant membrane disruption to cancer cells. The estimated IC50 of AA against the A549 cell line was 139.90 μg/mL. The highest synergistic activity was exhibited forming a zone of inhibition measuring 10mm when arjunolic acid and AqE of <em>T. asiatica </em>was added in the concentration of 1:1, respectively.
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2022-07-08 00:00:00
 
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http://op.niscair.res.in/index.php/IJEB/article/view/64073
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 60, ##issue.no## 07 (2022): IJEB [JULY 2022]
 
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