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<p>Synthesis of some ethoxyphthalimide derivatives of pyrazoloisoxazoles and pyrazolopyrimidines and their antimicrobial and anticancer screening</p>

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Title Statement <p>Synthesis of some ethoxyphthalimide derivatives of pyrazoloisoxazoles and pyrazolopyrimidines and their antimicrobial and anticancer screening</p>
 
Added Entry - Uncontrolled Name Joshi, Swati ; Department of Chemistry, Swami Keshvanand Institute of Technology, Management and Gramothan, Jaipur 302 017, Rajasthan, India
Talesara, G L ; Department of Chemistry, Mohan Lal Sukhadia University, Udaipur 313 001, Rajasthan, India
Talesara, G L ; Department of Chemistry, Mohan Lal Sukhadia University, Udaipur 313 001, Rajasthan, India
 
Uncontrolled Index Term Ethoxyphthalimide, pyrazoloisoxazoles, pyrazolopyrimidines, antimicrobial, anticancer
 
Summary, etc. <p class="normal" style="text-align: justify;">Synthesis of 4-arylidene-5-methyl-2,4-dihydro-3<em>H</em>-pyrazol-3-one (<strong>IIIa-d</strong>) has been achieved by the condensation reaction between 5-methyl-2,4-dihydro-3<em>H</em>-pyrazol-3-one (<strong>I</strong>) and 4-substituted benzaldehydes (<strong>IIa-d</strong>). Ethyl acetoacetate and hydrazine hydrate in absolute alcohol undergo cyclization reaction to give (<strong>I</strong>). 4-Arylidene-5-methyl-2,4-dihydro-3<em>H</em>-pyrazol-3-ones (<strong>IIIa-d</strong>) have been converted to corresponding ethoxyphthalimide derivatives (<strong>IVa-d</strong>) by treatment with phthalimidoxyethyl bromide (<strong>A</strong>). 1-N-Ethoxyphthalimido-3-methyl-4-(4-substituted benzylidene) pyrazol-5-one (<strong>IVa-d</strong>) has been reacted with hydroxylamine hydrochloride and guanidine nitrate separately to yield ethoxyphthalimide substituted pyrazolo[3,4-c]isoxazoles (<strong>Va-d</strong>) and pyrazolo[3,4-d]pyrimidines (<strong>VIa-d</strong>) respectively. All the compounds have been characterized by elemental and spectral analysis mainly IR, <sup>1</sup>H NMR and mass spectroscopy. Synthesized compounds have also been screened for various biological activities <em>viz.</em> antibacterial, antifungal, antiviral and anticancer.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-07-18 17:03:37
 
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http://op.niscair.res.in/index.php/IJC/article/view/64633
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 7 (2022): Indian Journal of Chemistry-(IJC)
 
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