Record Details

<p>Synthesis, molecular docking, antiproliferative and radical scavenging activities of vanillin derived 1,3,5-trisubstituted 2-pyrazolines</p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p>Synthesis, molecular docking, antiproliferative and radical scavenging activities of vanillin derived 1,3,5-trisubstituted 2-pyrazolines</p>
 
Added Entry - Uncontrolled Name R Deshpande, Shreenivas ; Department of Medicinal and Pharmaceutical Chemistry, Hanagal Shri Kumareshwar College of Pharmacy, BVVS Old Campus, Bagalkote-587 101, Karnataka, India
Malagi, Prasad V ; Department of Medicinal and Pharmaceutical Chemistry, Hanagal Shri Kumareshwar College of Pharmacy, BVVS Old Campus, Bagalkote-587 101, Karnataka, India
Malagi, Prasad V ; Department of Medicinal and Pharmaceutical Chemistry, Hanagal Shri Kumareshwar College of Pharmacy, BVVS Old Campus, Bagalkote-587 101, Karnataka, India
Jalihal, Prabhu C ; Department of Medicinal and Pharmaceutical Chemistry, Hanagal Shri Kumareshwar College of Pharmacy, BVVS Old Campus, Bagalkote-587 101, Karnataka, India
Jalihal, Prabhu C ; Department of Medicinal and Pharmaceutical Chemistry, Hanagal Shri Kumareshwar College of Pharmacy, BVVS Old Campus, Bagalkote-587 101, Karnataka, India
Mandalmari, Manappa T ; Department of Medicinal and Pharmaceutical Chemistry, Hanagal Shri Kumareshwar College of Pharmacy, BVVS Old Campus, Bagalkote-587 101, Karnataka, India
Mandalmari, Manappa T ; Department of Medicinal and Pharmaceutical Chemistry, Hanagal Shri Kumareshwar College of Pharmacy, BVVS Old Campus, Bagalkote-587 101, Karnataka, India
 
Uncontrolled Index Term Chalcones; Benzhydrazide, Isonicotiniacid hydrazide, MTT assay, Antioxidant, In Silico ADME analysis
 
Summary, etc. <p style="text-align: justify;">Observing the good anticancer potential of 2-pyrazoline scaffold, a panel of 1,3,5- trisubstituted 2- pyrazolinesnamely, 5-(4-hydroxy-3-methoxyphenyl)-3-(4-substitutedphenyl)4,5-dihydro-1H-pyrazol-1 yl)(phenyl)methanones 2a-j and (5-(4-hydroxy-3-methoxyphenyl)-3-(4-substituted phenyl)4,5-dihydro-1H-pyrazol-1-yl)(pyridin-4-yl)methanones 3a-j have been synthesized from the chalcone intermediates derived from the reaction between vanillin and substituted acetophenones, by condensing with benzhydrazide and isonicotinic acid hydrazide, respectively. The synthesized compounds have been characterized by spectral studies and screened for <em>in vitro </em>antiproliferative activity against human non small cell lung cancer cell line A549 by MTT assay and antioxidant activity by DPPH radical scavenging assay. The compound 2i has exhibited good antiproliferative activity followed by 2g and 2a. Compounds of both series 2a-j and 3a-j exhibited good radical scavenging activity. Molecular docking studies of 2h and 2j has revealed the good interaction with 3LCT (Crystal structure of anaplastic lymphoma kinase catalytic domain) receptor <em>via</em> hydrogen bonds, electrostatic and hydrophobic interactions. The drug-likeness properties of the compounds were also satisfactory leaving a good scope for further work.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-07-18 17:03:37
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJC/article/view/64634
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 7 (2022): Indian Journal of Chemistry-(IJC)
 
Language Note en