ICAR Research Data Repository for Knowledge Management
An efficient and scalable synthesis of Isodesmosine
DIR@IMTECH: CSIR-Institute of Microbial Technology
View Archive Info| Field | Value | |
| Title |
An efficient and scalable synthesis of Isodesmosine
|
|
| Creator |
Gupta, Aikan
Sharma, Yogesh Pawar, Ganesh P. Ashish , Ashish Nihalani, D Chaudhari, Vinod |
|
| Subject |
QR Microbiology
|
|
| Description |
Isodesmosine is 1,2,3,5-tetrasubstituted pyridinium-based amino acid substituted with four lysine derivatives found in elastin which is the main component of elastic fiber. Elastin plays a vital role in providing stretchy properties to tissues and body organs. Isodesmsoine is a proven to be useful biomarker for elastin degradation during the progressing stage of chronic obstructive pulmonary disease (COPD) and related diseases. The present work reported an efficient and gram-scale approach for the synthesis of Isodesmosine, starting from readily available Boc-Asp-OtBu using mild reaction conditions.
|
|
| Publisher |
Wiley
|
|
| Date |
2022-05
|
|
| Type |
Article
PeerReviewed |
|
| Relation |
https://onlinelibrary.wiley.com/doi/10.1002/jhet.4441
http://crdd.osdd.net/open/2977/ |
|
| Identifier |
Gupta, Aikan and Sharma, Yogesh and Pawar, Ganesh P. and Ashish , Ashish and Nihalani, D and Chaudhari, Vinod (2022) An efficient and scalable synthesis of Isodesmosine. Journal of Heterocyclic Chemistry, 59 (5). pp. 958-963.
|
|