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<strong>Manufacturing of chitosan based drug release systems from tamarind shells for long-term and effective methylprednisolone sodium succinate release</strong>

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Title Statement <strong>Manufacturing of chitosan based drug release systems from tamarind shells for long-term and effective methylprednisolone sodium succinate release</strong>
 
Added Entry - Uncontrolled Name Karaca Açarı, İdil
 
Uncontrolled Index Term Chitosan; Drug delivery systems; Methylprednisolone sodium succinate; Tamarind shell particles
 
Summary, etc. <p><span>In this study a microparticular drug delivery system containing tamarind shell and chitosan has been developed to realize the controlled release of methylprednisolone sodium succinate an important corticosteroid. Drug-loaded tamarind shells are coated with chitosan for a pH-controlled release. The release kinetics of the system have been examined in detail at three different pH ranges (3, 5 and 7.4). In our pH sensitive release systems a slow release up to 39.02%±0.81 at pH=7.4 at 72 hours. But we see that there is a faster release at 70.58±1.73% at pH=5 and 96.68±1.70% at pH=3 in 72 hours. Rapid release in acidic media depends on the solubility of the chitosan structure in acidic environments. It is believed that the pH sensitive carrier system obtained within the scope of the study will have a high potential for use in many biomedical application areas (wound surface application, etc.).</span></p>
 
Publication, Distribution, Etc. Indian Journal of Chemical Technology (IJCT)
2022-07-26 11:23:21
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJCT/article/view/56876
 
Data Source Entry Indian Journal of Chemical Technology (IJCT); ##issue.vol## 29, ##issue.no## 3 (2022): Indian Journal of Chemical Technology
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCT/article/download/56876/465585567
http://op.niscair.res.in/index.php/IJCT/article/download/56876/465585568