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<p>Hepatoprotective effect of combined extracts of <em>Andrographis paniculata, Boerhavia</em><br /><em>diffusa, Eclipta alba</em> and <em>Picrorhiza kurroa</em> on carbon tetrachloride and<br />paracetamol-induced hepatotoxicity in rats</p>

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Title Statement <p>Hepatoprotective effect of combined extracts of <em>Andrographis paniculata, Boerhavia</em><br /><em>diffusa, Eclipta alba</em> and <em>Picrorhiza kurroa</em> on carbon tetrachloride and<br />paracetamol-induced hepatotoxicity in rats</p>
 
Added Entry - Uncontrolled Name Nanjaian, Mahadevan ; King Khalid University
Goyal, Munish ; Aakash Institute of Medical Sciences, Solan, India
Vasudevan, Rajalakshimi ; College of Pharmacy King Khalid University, Abha
Khan, Noohu Abdulla; College of Pharmacy King Khalid University, Abha
Chidambaram, Kumarappan ; Assistant Professor College of Pharmacy King Khalid University, Abha Kingdom of Saudi Arabia
 
Uncontrolled Index Term Carbon tetrachloride, Extract, Hepatoprotective, Paracetamol, Transaminases
 
Summary, etc. <p>Extracts obtained from <em>Andrographis paniculata, Boerhavia diffusa, Eclipta alba </em>and<em> Picrorhiza kurroa </em>were mixed in an equal ratio and the combined extract was evaluated for the hepatoprotective activity against carbon tetrachloride and paracetamol induced hepatotoxicity in rats. The hepatotoxicants increased the levels of transaminases, total bilirubin, triglycerides and decreased the level of albumin in the serum of rat. Liver homogenate of the rats showed an increase in the lipid peroxidation level and reduction in the levels of glutathione. The rats administered with the combined extract reversed the biochemical parameters reflecting the liver function. The combined extract showed significant (P &lt; 0.05) dose dependent hepatoprotective activity against the toxicants as it was evident from the values of biochemical parameters when compared to silymarin administered animals. The results showed that the recovery exhibited by the combined extract at 400 mg/kg dose level was highest among other doses tested and was well comparable to silymarin treated rats.</p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2022-07-26 07:24:30
 
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http://op.niscair.res.in/index.php/IJTK/article/view/32239
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 21, ##issue.no## 3 (2022): Indian Journal of Traditional Knowledge
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJTK/article/download/32239/465499407
http://op.niscair.res.in/index.php/IJTK/article/download/32239/465499408
http://op.niscair.res.in/index.php/IJTK/article/download/32239/465499409
http://op.niscair.res.in/index.php/IJTK/article/download/32239/465499410