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Phytochemical evaluation and anti-psoriatic activity of the ethanolic extract of the leaves of <em>Momordica charantia</em>

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Title Statement Phytochemical evaluation and anti-psoriatic activity of the ethanolic extract of the leaves of <em>Momordica charantia</em>
 
Added Entry - Uncontrolled Name Dwarampudi, L Priyanka
SP, Dhanabal
Farha, Sayyeda
Gade, Ramya
R, Shanmugam
R, Krishna Raj
 
Uncontrolled Index Term Alcoholic soxhlation method; Ascorbic acid; Momordica charantia; Mouse tail model; Orthokeratosis; Psoriasis
 
Summary, etc. Psoriasis is a chronic, inflammatory, multi factorial disease. Topical chemical agents are used to treat psoriasis, despite their lower effectiveness or ineffective effects. Herbal medicine can be one of the alternative treatment methods. Momordica charantia is traditionally used to treat skin diseases, especially psoriasis. The main phytochemicals responsible for antipsoriatic activity is stigmasterol, taraxerol, lofenol, phenylpropanoids and squalene. The alcoholic soxhlation method was used to obtain the percentage phytochemical yield of 13.36% w/w, which was used for antipsoriatic activity using a mouse tail model of psoriasis. The extract produced significant differentiation of the epidermis as evidenced by the degree of orthokeratosis 70.18 ± 2.64% compared to the negative control 17.30 ± 4.09%. This was equivalent to the effect of the standard positive control, tazarotene gel (0.1%), which showed a degree of orthokeratosis of 90.03 ± 2.00%. The extract showed an overall antipsoriatic activity of 63.94%.
 
Publication, Distribution, Etc. Indian Journal of Biochemistry and Biophysics (IJBB)
2022-07-29 13:41:38
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJBB/article/view/57759
 
Data Source Entry Indian Journal of Biochemistry and Biophysics (IJBB); IJBB Vol. 59 (7) [July 2022]
 
Language Note en