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<p>Therapeutic effect of propolis on <em>Staphylococcus aureus</em> induced oxidative stress in kidney of BALB/c mice. A biochemical and histopathological study</p>

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Title Statement <p>Therapeutic effect of propolis on <em>Staphylococcus aureus</em> induced oxidative stress in kidney of BALB/c mice. A biochemical and histopathological study</p>
 
Added Entry - Uncontrolled Name Rana, Anita ; Dept of Biosciences (UIBT), Chandigarh University, NH-95, Ludhiana - Chandigarh State Hwy, Punjab 140413.
Kumar, Neelima R; Professor, Department of Zoology, Panjab University, Chandigarh, India.
Kaur, Jaspreet ; Department of Biotechnology, Panjab University, Chandigarh, India
 
Uncontrolled Index Term Amoxicillin; Ampicillin; Antioxidative potential; Apitherapy; Bee glue Multidrug-resistance (MDR)
 
Summary, etc. Due to emerging drug resistance in pathogenic organisms, most of the second generation antibiotics are not effective in controlling the disease. As a consequence, the dosage and duration of drug intake has increased leading to drug induced toxicity and various side effects. A large number of natural products are being reported to ameliorate the toxicity and oxidative stress caused by antibiotics. Here, we explored the antioxidative potential of honey bee product propolis alone as well as in combination with antibiotics in <em>Staphylococcus aureus </em>infected BALB/c mice. For experimental design, mice were divided in to seven groups and decapitated after experimental period. Kidney was excised, homogenized and then used for different biochemical and histopathological estimations. Results observed after treatment with propolis and antibiotics were compared with those of <em>S. aureus</em> infected group. Results showed increase in lipid peroxidation, decrease in reduced glutathione levels and antioxidant enzymes such as; catalase, superoxide dismutase, glutathione-S-transferase, glutathione peroxidase and glutathione reductase. On the contrary, treatment with propolis, led to reduction in levels of LPO and increase in activities of antioxidant enzymes. Also, histopathology of kidney and all kidney function enzymes were restored to near normal.<br />
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2022-08-01 00:00:00
 
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http://op.niscair.res.in/index.php/IJEB/article/view/54823
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 60, ##issue.no## 08 (2022): IJEB [AUGUST 2022]
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJEB/article/download/54823/465577421
http://op.niscair.res.in/index.php/IJEB/article/download/54823/465577422
http://op.niscair.res.in/index.php/IJEB/article/download/54823/465577424