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Manufacturing of chitosan based drug release systems from tamarind shells for long-term and effective methylprednisolone sodium succinate release

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Title Manufacturing of chitosan based drug release systems from tamarind shells for long-term and effective methylprednisolone sodium succinate release
 
Creator Açarı, İdil Karaca
 
Subject Chitosan
Drug delivery systems
Methylprednisolone sodium succinate
Tamarind shell particles
 
Description 240-250
In this study a microparticular drug delivery system containing tamarind shell and chitosan has been developed to realize the controlled release of methylprednisolone sodium succinate an important corticosteroid. Drug-loaded tamarind shells are coated with chitosan for a pH-controlled release. The release kinetics of the system have been examined in detail at three different pH ranges (3, 5 and 7.4). In our pH sensitive release systems a slow release up to 39.02%±0.81 at pH=7.4 at 72 hours. But we see that there is a faster release at 70.58±1.73% at pH=5 and 96.68±1.70% at pH=3 in 72 hours. Rapid release in acidic media depends on the solubility of the chitosan structure in acidic environments. It is believed that the pH sensitive carrier system obtained within the scope of the study will have a high potential for use in many biomedical application areas (wound surface application, etc.).
 
Date 2022-06-27T09:49:07Z
2022-06-27T09:49:07Z
2022-05
 
Type Article
 
Identifier 0975-0991 (Online); 0971-457X (Print)
http://nopr.niscpr.res.in/handle/123456789/59938
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJCT Vol.29(3) [May 2022]