Manufacturing of chitosan based drug release systems from tamarind shells for long-term and effective methylprednisolone sodium succinate release
NOPR - NISCAIR Online Periodicals Repository
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Title |
Manufacturing of chitosan based drug release systems from tamarind shells for long-term and effective methylprednisolone sodium succinate release
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Creator |
Açarı, İdil Karaca
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Subject |
Chitosan
Drug delivery systems Methylprednisolone sodium succinate Tamarind shell particles |
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Description |
240-250
In this study a microparticular drug delivery system containing tamarind shell and chitosan has been developed to realize the controlled release of methylprednisolone sodium succinate an important corticosteroid. Drug-loaded tamarind shells are coated with chitosan for a pH-controlled release. The release kinetics of the system have been examined in detail at three different pH ranges (3, 5 and 7.4). In our pH sensitive release systems a slow release up to 39.02%±0.81 at pH=7.4 at 72 hours. But we see that there is a faster release at 70.58±1.73% at pH=5 and 96.68±1.70% at pH=3 in 72 hours. Rapid release in acidic media depends on the solubility of the chitosan structure in acidic environments. It is believed that the pH sensitive carrier system obtained within the scope of the study will have a high potential for use in many biomedical application areas (wound surface application, etc.). |
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Date |
2022-06-27T09:49:07Z
2022-06-27T09:49:07Z 2022-05 |
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Type |
Article
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Identifier |
0975-0991 (Online); 0971-457X (Print)
http://nopr.niscpr.res.in/handle/123456789/59938 |
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Language |
en
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Publisher |
NIScPR-CSIR, India
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Source |
IJCT Vol.29(3) [May 2022]
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