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Ginseng used for bone tissue scaffold

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Title Ginseng used for bone tissue scaffold
 
Creator Paul, Samrat
Choudhury, Mahima
Sen, Sohini
Basak, Piyali
 
Subject Ginseng scaffold
Honeycomb scaffold
MC3T3 E1 cell
Regenarative therapy
 
Description 696-701
The scaffold based tissue engineering materialized for bone
tissue therapy. Gelatin-glutaraldehyde cross linked scaffold was
prepared by solvent casting -porogen leaching method. It was
characterized by FTIR and SEM microphotograph analysis.
Absence of peak at waves no. 1625 cm−1 in ATR-FTIR indicated
formation of cross-linking. FE-SEM micrograph showed
honeycomb pad like structure with high porosity. Methanolic
extract of Withania somnifera (Ashwagandha) root extract
induced MC3T3 E1 osteoblast cell adhesion and proliferation on
porous gelatin scaffold. GC-MS analysis pointed out presence of
4-amino- 2-ethyl-3-methylquinoline, an active phyto-chemicals
having tissue regeneration potential. High anti-oxidant capacity
down regulates cell death mechanism by scavenging free radical.
The biocompatible gelatin scaffold has RGD moiety that attune
the MC3T3 E1 osteoblast cell adhesion. Withania somnifera root
extract may boost up cell proliferation on scaffold. Therefore
treatment with Withania somnifera root extract may be the new
approaches for designing bone tissue scaffold for bone tissue
therapy.
 
Date 2022-07-01T10:55:09Z
2022-07-01T10:55:09Z
2022-06
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/60006
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.59(6) [June 2022]