Record Details

Molecular docking and Antibacterial activities of Cobalt (II) complexes derived from precursors of Hydrazones

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Molecular docking and Antibacterial activities of Cobalt (II) complexes derived from precursors of Hydrazones
 
Creator Kothari, Richa
Agrawal, Anurag
Rai, Sanchita
 
Subject Antibacterial activity
Cobalt complexes
Disc diffusion method
Schiff base ligands
Spectroscopic characterization
 
Description 640-652
The Schiff base ligands in their deprotonated forms have been utilized to synthesize thermodynamically and kinetically stabilized Cobalt(II) complexes. In the complexes, cobalt ion present is in distorted octahedral arrangement and is coordinated by four tridentate ligands in complexes. The synthesized Schiff base ligands coordinate with Cobalt (II) ion through four azomethine nitrogen atoms and two sulfur atoms developing a 6- membered chelate ring. Synthesized Cobalt(II) complexes via hexadentate ligands have been characterized thoroughly through various spectroscopic techniques like FT-IR, UV-Vis, 1HNMR, TGA, TEM, SEM, Particle size, Elemental analysis (C, H, N, Co, S) and conductivity measurements. All Cobalt(II) complexes have been evaluated for in vitro antimicrobial activity against isolated bacterial strains of E. coli (MTCC-1687), E. faecalis (MTCC-439), S. aureus (MTCC-737) and MR S. aureus (Indigenous). All Cobalt complexes show mild to moderate antibacterial activity. The MIC ranged from 50 μg/ mL to 3.125 μg/ mL. All Cobalt(II) complexes displayed in-vitro antibacterial activity against both gram-positive and gram-negative bacterial strains. It may be proved that the antibacterial activity of the complexes is related to the cell wall structure of the tested bacteria. In-vitro toxicity tests explained the Cobalt complexes were less cytotoxic than the Vancomycin drug on A431 cancer cell lines and the results explain that synthesized Cobalt complexes can act as potent antimicrobial agents and can be considered as a good drug candidate for medicinal chemistry researchers.
 
Date 2022-07-01T11:05:38Z
2022-07-01T11:05:38Z
2022-06
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/60011
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.59(6) [June 2022]