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Antiproliferative potential of Sargassum binderi Sonder ex J. Agardh mediated biogenic silver/silver chloride nanoparticles on EAC, MCF-7 and HCT116 cells

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Title Antiproliferative potential of Sargassum binderi Sonder ex J. Agardh mediated biogenic silver/silver chloride nanoparticles on EAC, MCF-7 and HCT116 cells
 
Creator Ahamed, M S
Rahman, M M
Hasan, I
Kabir, S R
Asaduzzaman, A K M
 
Subject Ag/AgCl-NPs
Apoptosis
Cancer cell inhibition
Gene expression
Sargassum binderi
 
Description 126-137
Biosynthesis of Ag/AgCl-NPs from Sargassum binderi extract was confirmed by colour changes and a sharp peak at
416 nm detected by UV-visible spectrophotometer. It was characterized by Transmission Electron Microscopy (TEM),
Energy Dispersive X-ray (EDX) spectrophotometer, X-ray powder Diffraction (XRD) and Fourier-Transform Infrared
Spectroscopy (FTIR). Mild toxicity of the synthesized Ag/AgCl-NPs was determined by the brine shrimp nauplii
cytotoxicity assay. IC50 values of 19.73, 25.56, and 14.00 𝜇g/ml showed the growth inhibition of Ehrlich Ascites Carcinoma
(EAC), human breast cancer (MCF-7) and human colon cancer (HCT116) cells by Ag/AgCl-NPs, respectively. By
analyzing cell morphological study using annexin V and caspase-3 inhibitor, initiation of apoptosis in EAC cells was
confirmed. The results were further supported through the expression of several genes, where, p53 and Bax genes became
activated and Bcl-X and NFκB genes were suppressed.
 
Date 2022-07-01T11:48:51Z
2022-07-01T11:48:51Z
2022-02
 
Identifier 2582-6727 (Online); 2582-6506 (Print)
http://nopr.niscpr.res.in/handle/123456789/60024
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJMS Vol.51(02) [February 2022]