Hypervalent iodine mediated solid state synthesis of 2-aryl-5- [2-(3,4,5-trimethoxyphenyl)[1,8]naphthyridin- 3-yl]-1,3,4-oxadiazoles
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Title |
Hypervalent iodine mediated solid state synthesis of 2-aryl-5- [2-(3,4,5-trimethoxyphenyl)[1,8]naphthyridin- 3-yl]-1,3,4-oxadiazoles
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Creator |
Challa, Pradeep Kumar
Ega, Jagadeesh Kumar |
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Subject |
1,8-Naphthyridine
PhI(OAc)2 SiO2-FeCl3 Oxadiazoles |
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Description |
635-639
The hydrazones 5 on oxidative cyclization of with [PhI(OAc)2] in the solid state at room temperature under grinding conditions has furnished the respective 2-aryl-5-[2-(3,4,5-trimethoxyphenyl)[1,8]naphthyridin-3-yl]-1,3,4-oxadiazoles 6 in good yields without any undesirable byproducts. The purity of the products is high. The method is preoperatively convenient, useful and environmentally benign. The experimental procedure is very simple and avoids sophistication. The most probable mechanism of above transformation is suggested. The structure of compounds 5 and 6 has been confirmed by their spectroscopic(IR, 1H NMR and MS) and analytical data. |
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Date |
2022-07-05T10:43:20Z
2022-07-05T10:43:20Z 2022-06 |
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Type |
Article
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Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60031 |
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Language |
en
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Publisher |
NIScPR-CSIR, India
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Source |
IJC Vol.61(06) [June 2022]
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