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Synthesis, characterization and investigation of antimicrobial and antioxidant activities of some new 2-[(4,5-dihydro-1H-1,2,4-triazol-5-one-4- yl)azomethine]phenyl 4-nitrobenzoate derivatives

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Title Synthesis, characterization and investigation of antimicrobial and antioxidant activities of some new 2-[(4,5-dihydro-1H-1,2,4-triazol-5-one-4- yl)azomethine]phenyl 4-nitrobenzoate derivatives
 
Creator Yüksek, H
Berkyürek, A
Manap, S
Özdemir, G
Beytur, M
Balseven, H
Alkan, M
FAytemiz
Gürsoy-Kol, Ö
 
Subject 1,2,4-Triazol-5-one
Schiff base
Mannich base
acetylation
antioxidant activity
antimicrobial activity
 
Description 623-634
The synthesis of 2-{[3-alkyl(aryl)-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl]azomethine}-phenyl 4-nitrobenzoates 3from the
reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 1 with 2-(4-nitrobenzoxy)-benzaldehyde 2is described. The
acetylation reactions of the compounds 3 giving compounds 4 have been investigated. The compounds 3 have also been treated
with 4-piperidinecarboxamide / piperazine in the presence of formaldehyde according to the Mannich reaction to synthesize 2-{[1-
(4-piperidinecarboxamide-1-yl-methyl)-3-alkyl(aryl)-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl]azomethine}-phenyl 4-benzoates 5
and N,N´-bis-{3-alkyl(aryl)-4-[2-(4-nitrobenzoxy)-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-on-1-yl-methyl}-piperazines
6. The newly synthesized compounds have been characterized using IR, 1H and 13C NMR, UV-Vis and mass spectral data. In
addition, the newly synthesized compounds have been screened for their antimicrobial activities. Furthermore, these thirty one new
compounds have been analyzed for their in vitro potential antioxidant activities by three different methods.
 
Date 2022-07-05T10:48:02Z
2022-07-05T10:48:02Z
2022-06
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60032
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.61(06) [June 2022]