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Design, synthesis and in vitro antimicrobial activity of fused pyridine-pyrimidine hybrids

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Title Design, synthesis and in vitro antimicrobial activity of fused pyridine-pyrimidine hybrids
 
Creator Desai, Nisheeth C
Khasiya, Ashvinkumar G
 
Subject Pyridine
Pyrimidine
Antibacterial activity
Antifungal activity
 
Description 582-590
The antimicrobial resistance (AMR) is defined as the rising global concern of infectious illnesses that are resistant to all
known antimicrobial agents. As the microbial resistance is increasing recently against the present therapeutics, there is an
urgency to discover the novel antimicrobial agents. Due to this reason, we have synthesized a series of novel pyridinepyrimidine
derivatives (4a-o) for the development of antimicrobial agents. The structures of these bioactive molecules were
determined using IR, 1H NMR, 13C NMR, and mass spectroscopy. The titled compounds were tested for antimicrobial
activity against various bacterial and fungal strains using Chloramphenicol and Griseofulvin as standard drugs. Compounds
4b, 4d and 4m exhibited excellent antibacterial activity with MIC = 62.5 μg/mL against E. coli, S. aureus and S. pyogenes
respectively. Compounds 4g and 4o showed prominent activity against C. albicans with MIC value of 250 μg/mL.
 
Date 2022-07-05T11:04:29Z
2022-07-05T11:04:29Z
2022-06
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60037
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.61(06) [June 2022]