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The application value of a new Zn(II) coordination polymer in the early diagnosis and treatment of infantile rickets

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Title The application value of a new Zn(II) coordination polymer in the early diagnosis and treatment of infantile rickets
 
Creator Lv, Xiaoqian
Liu, Na
Yin, Zhanru
 
Subject Coordination polymer
infantile rickets
molecular docking
 
Description 771-775
In the present study, a new 1D Zn(II) coordination polymer (CP) on the basis of 2,5-bis(pyridine-2-yl)-1,3,4-thiadiazole
(L) as linking ligand with the chemical formula of [ZnLCl2]n has been created via blending L with Zn salt (ZnCl2) and
studied through single crystal X-ray diffraction and elemental analysis. Its application values on the early diagnosis and
treatment of infantile rickets were determined and the relevant mechanism was studied in the meanwhile. Then, the QCT
was used to measure the bone density of the infantile rickets animal after adding compound. Moreover, the activity of the
wnt signaling routine in the bone tissue was assessed via real time RT-PCR. By investigating into the detail of the binding
conformation from a molecular level, molecular docking simulation reveals that the expected biological activity of the Zn
complex comes from the pyridine group.
 
Date 2022-07-15T10:54:34Z
2022-07-15T10:54:34Z
2022-07
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60107
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.61(07) [July 2022]