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Synthesis of some ethoxyphthalimide derivatives of pyrazoloisoxazoles and pyrazolopyrimidines and their antimicrobial and anticancer screening

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Title Synthesis of some ethoxyphthalimide derivatives of pyrazoloisoxazoles and pyrazolopyrimidines and their antimicrobial and anticancer screening
 
Creator Joshi, Swati
Talesara, G L
 
Subject Ethoxyphthalimide
pyrazoloisoxazoles
pyrazolopyrimidines
antimicrobial
anticancer
 
Description 723-731
Synthesis of 4-arylidene-5-methyl-2,4-dihydro-3H-pyrazol-3-one (IIIa-d) has been achieved by the condensation
reaction between 5-methyl-2,4-dihydro-3H-pyrazol-3-one (I) and 4-substituted benzaldehydes (IIa-d). Ethyl acetoacetate
and hydrazine hydrate in absolute alcohol undergo cyclization reaction to give (I). 4-Arylidene-5-methyl-2,4-dihydro-3Hpyrazol-
3-ones (IIIa-d) have been converted to corresponding ethoxyphthalimide derivatives (IVa-d) by treatment with
phthalimidoxyethyl bromide (A). 1-N-Ethoxyphthalimido-3-methyl-4-(4-substituted benzylidene) pyrazol-5-one (IVa-d)
has been reacted with hydroxylamine hydrochloride and guanidine nitrate separately to yield ethoxyphthalimide substituted
pyrazolo[3,4-c]isoxazoles (Va-d) and pyrazolo[3,4-d]pyrimidines (VIa-d) respectively. All the compounds have been
characterized by elemental and spectral analysis mainly IR, 1H NMR and mass spectroscopy. Synthesized compounds have
also been screened for various biological activities viz. antibacterial, antifungal, antiviral and anticancer.
 
Date 2022-07-15T11:04:44Z
2022-07-15T11:04:44Z
2022-07
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60112
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.61(07) [July 2022]