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Hepatoprotective effect of combined extracts of Andrographis paniculata, Boerhavia diffusa, Eclipta alba and Picrorhiza kurroa on carbon tetrachloride and paracetamol-induced hepatotoxicity in rats

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Title Hepatoprotective effect of combined extracts of Andrographis paniculata, Boerhavia diffusa, Eclipta alba and Picrorhiza kurroa on carbon tetrachloride and paracetamol-induced hepatotoxicity in rats
 
Creator Mahadevan, Nanjaian
Goyal, Munish
Rajalakshimi, Vasudevan
Khan, Noohu Abdulla
Chidambaram, Kumarappan
 
Subject Carbon tetrachloride
Extract
Hepatoprotective
Paracetamol
Transaminases
 
Description 545-551
Extracts obtained from Andrographis paniculata, Boerhavia diffusa, Eclipta alba and Picrorhiza kurroa were mixed in
an equal ratio and the combined extract was evaluated for the hepatoprotective activity against carbon tetrachloride and
paracetamol-induced hepatotoxicity in rats. The hepatotoxicants increased the levels of transaminases, total bilirubin,
triglycerides and decreased the level of albumin in the serum of rat. Liver homogenate of the rats showed an increase in the
lipid peroxidation level and reduction in the levels of glutathione. The rats administered with the combined extract reversed
the biochemical parameters reflecting the liver function. The combined extract showed significant (p
 
Date 2022-07-28T11:54:14Z
2022-07-28T11:54:14Z
2022-07
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/60200
 
Language en
 
Relation Int Cl.22: A61K 9/00, A61K 36/00, A61P 1/16
 
Publisher NIScPR-CSIR, India
 
Source IJTK Vol.21(3) [July 2022]