Hepatoprotective effect of combined extracts of Andrographis paniculata, Boerhavia diffusa, Eclipta alba and Picrorhiza kurroa on carbon tetrachloride and paracetamol-induced hepatotoxicity in rats
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Title |
Hepatoprotective effect of combined extracts of Andrographis paniculata, Boerhavia diffusa, Eclipta alba and Picrorhiza kurroa on carbon tetrachloride and paracetamol-induced hepatotoxicity in rats
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Creator |
Mahadevan, Nanjaian
Goyal, Munish Rajalakshimi, Vasudevan Khan, Noohu Abdulla Chidambaram, Kumarappan |
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Subject |
Carbon tetrachloride
Extract Hepatoprotective Paracetamol Transaminases |
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Description |
545-551
Extracts obtained from Andrographis paniculata, Boerhavia diffusa, Eclipta alba and Picrorhiza kurroa were mixed in an equal ratio and the combined extract was evaluated for the hepatoprotective activity against carbon tetrachloride and paracetamol-induced hepatotoxicity in rats. The hepatotoxicants increased the levels of transaminases, total bilirubin, triglycerides and decreased the level of albumin in the serum of rat. Liver homogenate of the rats showed an increase in the lipid peroxidation level and reduction in the levels of glutathione. The rats administered with the combined extract reversed the biochemical parameters reflecting the liver function. The combined extract showed significant (p |
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Date |
2022-07-28T11:54:14Z
2022-07-28T11:54:14Z 2022-07 |
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Type |
Article
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Identifier |
0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/60200 |
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Language |
en
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Relation |
Int Cl.22: A61K 9/00, A61K 36/00, A61P 1/16
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Publisher |
NIScPR-CSIR, India
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Source |
IJTK Vol.21(3) [July 2022]
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