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Nutmeg extract modulates triglyceride levels and gene expressions of CD36, FATP1, and CPT1B in rat skeletal muscle

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Title Nutmeg extract modulates triglyceride levels and gene expressions of CD36, FATP1, and CPT1B in rat skeletal muscle
 
Creator R, Lesmana
S, Husen
Y S, Pratiwi
S, Susianti
H, Goenawan
K, Lestari
R, Abdulah
M R A, Syamsunarno
N, Anggraeni
A, Purba
U, Supratman
 
Subject CD36
CPT1B
FATP1
Lipid
Nutmeg
Soleus muscle
 
Description 531-536
Obesity has become a global health problem. It affects all organs in the human body including skeletal muscle as fat
deposits in skeletal muscle. Myristica fragrans (nutmeg), which is a native spice from Indonesia, has been used in daily basis
and have potential effect to hyperlipidemia. Various in vivo studies have been proven that nutmeg extract can reduce body
weight and lipid deposition. However, there is limited information about the effects of nutmeg on lipid transport regulation,
particularly in skeletal muscle cells. We investigated the effects of nutmeg extract on blood lipid profile and lipid metabolism in
skeletal muscles. Male Wistar rats were divided into two groups: control and nutmeg extract-treated group. The treatment group
consumed nutmeg extract for 12 weeks. Blood samples were collected for lipid profile examination. In addition, the soleus
muscles of all groups were isolated and collected for mRNA examination. The expression of lipid transporter in the cell
membrane (CD36) and mitochondrial membrane (FATP1 and CPT1B) were analyzed by semi-quantitative PCR. Although the
daily food intake increased, there was no weight gain in the nutmeg-treated group. Additionally, nutmeg extract has been shown
to decrease triglyceride blood levels in the treatment group. Interestingly, the CD36, FATP1 and CPT1B mRNA expressions in
the soleus muscles increased with nutmeg treatment. The results of this study suggest that nutmeg extract modulates lipid
utilization in skeletal muscle through CD36, FATP1 and CPT1B lipid transporter.
 
Date 2022-07-28T12:09:40Z
2022-07-28T12:09:40Z
2022-07
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/60202
 
Language en
 
Relation Int Cl.22: A61K 36/00
 
Publisher NIScPR-CSIR, India
 
Source IJTK Vol.21(3) [July 2022]