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Antimicrobial and anti-inflammatory response by two formulations of Jatyadi thailam in healing diabetic foot ulcers

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Title Antimicrobial and anti-inflammatory response by two formulations of Jatyadi thailam in healing diabetic foot ulcers
 
Creator Swathi, K
Sumathi, S
Kumar, Somit
Sripathi, Shubashini K
 
Subject Diabetic foot ulcers
Infection
Inflammation
Jatyadi thailam
Polyherbal Ayurvedic formulation
 
Description 489-498
Jatyadi thailam is a polyherbal formulation used by Ayurvedic practitioners and clinically reported for the treatment of inflammation related ailment specifically in non-healing chronic foot ulcers. The study is focused to validate and compare the Ayurvedic Formulary of India (AFI) and Yogagrantha (YG) formulations of Jatyadi thailam in vitro, for its antimicrobial and anti-inflammatory potential. Antimicrobial activity of thailam was determined by broth microdilution method for its minimal inhibitory concentration (MIC) and microbicidal activity (MBC/MFC). In vitro anti-inflammatory activity of varying concentrations of Jatyadi thailam were determined by assaying albumin denaturation inhibition, membrane stabilization (hypotonicity-induced hemolysis), heat induced hemolysis and antiproteinase activities. Highest bactericidal and fungicidal activity was recorded by AFI formulation of Jatyadi thailam showing low MIC values compared to YG formulation. Of all the tested bacterial strains, both the formulations showed great bactericidal effect against Staphylococcus aureus. Both the formulations exhibited significant dose dependent anti-denaturation and anti-proteinase activities. The thailam also showed marked stabilization of human red blood cell (HRBC) membrane against thermal hemolysis. Our study confirmed AFI formulation of Jatyadi thailam possessed better antimicrobial and significant (p
 
Date 2022-07-28T12:32:26Z
2022-07-28T12:32:26Z
2022-07
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/60207
 
Language en
 
Relation Int Cl.22: A61K 36/00, A61P 17/00, A61P 17/02
 
Publisher NIScPR-CSIR, India
 
Source IJTK Vol.21(3) [July 2022]