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Phytochemical evaluation and anti-psoriatic activity of the ethanolic extract of the leaves of Momordica charantia

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Title Phytochemical evaluation and anti-psoriatic activity of the ethanolic extract of the leaves of Momordica charantia
 
Creator Dwarampudi, L Priyanka
SP, Dhanabal
Farha, Sayyeda
Gade, Ramya
R, Shanmugam
R, Krishna Raj
 
Subject Alcoholic soxhlation method
Ascorbic acid
Momordica charantia
Mouse tail model
Orthokeratosis
Psoriasis
 
Description 751-754
Psoriasis is a chronic, inflammatory, multi factorial disease. Topical chemical agents are used to treat psoriasis, despite
their lower effectiveness or ineffective effects. Herbal medicine can be one of the alternative treatment methods. Momordica
charantia is traditionally used to treat skin diseases, especially psoriasis. The main phytochemicals responsible for antipsoriatic
activity is stigmasterol, taraxerol, lofenol, phenylpropanoids and squalene. The alcoholic soxhlation method was used to obtain
the percentage phytochemical yield of 13.36% w/w, which was used for antipsoriatic activity using a mouse tail model of
psoriasis. The extract produced significant differentiation of the epidermis as evidenced by the degree of orthokeratosis
70.18 ± 2.64% compared to the negative control 17.30 ± 4.09%. This was equivalent to the effect of the standard positive
control, tazarotene gel (0.1%), which showed a degree of orthokeratosis of 90.03 ± 2.00%. The extract showed an overall
antipsoriatic activity of 63.94%.
 
Date 2022-08-01T06:45:16Z
2022-08-01T06:45:16Z
2022-07
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/60225
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJBB Vol.59(7) [July 2022]