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Bioactive extract of mycelia biomass of Ganoderma lucidum protects doxorubicin induced cardiomyopathy

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Title Bioactive extract of mycelia biomass of Ganoderma lucidum protects doxorubicin induced cardiomyopathy
 
Creator Veena, Ravindran K
Ajith, Thekkuttuparambil A
Janardhanan, Kainoor K
 
Subject Anticancer drug toxicity
Chemotherapy
Cardiac injury markers
Lingzhi
Mushroom
Oxidative stress
Reishi
 
Description 587-596
Cardiotoxicity induced by anticancer drug; doxorubicin (DOX) is a limiting factor for its prolonged use in chemotherapy. No effective drug is currently available to prevent DOX induced cardiomyopathy. Ganoderma lucidum is highly valued medicinal mushroom used in traditional medicine. Mycelia biomasses are considered as alternate sources of mushroom bioactive compounds. We examined the effect of bioactive extract of G. lucidum mycelia biomass (GLME) to prevent cardiotoxicity induced by DOX in rats using a cumulative dose 18 mg/kg body wt. GLME was administered to animals at doses of 250 and 500 mg/kg body wt. once daily for five days prior to DOX administration and continued for three more days. Animals were sacrificed 24 h after the last dose of drug. Activities of creatine kinase (CK), lactate dehydrogenase (LDH), endogenous antioxidant status, oxidative stress markers, electrocardiograph (ECG) and haematological parameters were evaluated. DOX administration drastically elevated CK, LDH, myocardial peroxidation and oxidative stress and significantly lowered endogenous antioxidant activity. GLME administration attenuated elevated levels of CK, LDH and oxidative stress and also ameliorated alterations in haematological and ECG parameters. Results revealed that bioactive extract of G. lucidum mycelia imparted significant protection against DOX induced cardiomyopathy suggesting the potential therapeutic significance of G. lucidum mycelia bioactives to alleviate DOX induced cardiomyopathy.
 
Date 2022-08-01T11:40:34Z
2022-08-01T11:40:34Z
2022-08
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/60241
https://doi.org/10.56042/ijeb.v60i08.35341
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJEB Vol.60(08) [AUG 2022]