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<p style="text-align: justify;">Biologically active Amaryllidaceae alkaloids in <em>Narcissus pseudonarcissus</em> cv. Carlton and Andrew’s Choice dormant bulbs</p>

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Title Statement <p style="text-align: justify;">Biologically active Amaryllidaceae alkaloids in <em>Narcissus pseudonarcissus</em> cv. Carlton and Andrew’s Choice dormant bulbs</p>
 
Added Entry - Uncontrolled Name Das, Amit ; Department of Genetics and Plant Breeding, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh
Ferdausi, Aleya ; Department of Genetics and Plant Breeding, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh
Chang, Xianmin ; Crop Production Technology, Royal Agricultural University, Cirencester, Gloucestershire, GL7 6JS, United Kingdom
Jones, Meriel ; Functional and Comparative Genomics, Institute of Integrative Biology, The Biosciences Building, Crown Street, The University of Liverpool, Liverpool, L69 7ZB, United Kingdom
Commonwealth Scholarship Commission, UK
 
Uncontrolled Index Term Plant alkaloids
Amaryllidaceae alkaloids; Galanthamine; Gas chromatography; Narcissus pseudonarcissus; Pharmaceuticals.
 
Summary, etc. <p style="text-align: justify;">Since the ancient times, Amaryllidaceae genus <em>Narcissus</em> has been reported for the production of biologically important alkaloids, many of which are used as therapeutic tools for human diseases. Among them, galanthamine (Gal) has received a considerable attention for its acetylcholinesterase inhibitory activity for the treatment of early to mid-stage Alzheimer’s diseases. In this study, gas chromatography-mass spectrophotometry was used to determine the galanthamine content along with the detection of other biologically important alkaloids in dormant bulb and basal plate of two cultivated varieties of <em>Narcissus pseudonarcissus</em>, Carlton and Andrew’s Choice. The amount of galanthamine was higher in Carlton bulb (860 µg Gal/g) and basal plate (1254 µg Gal/g) than Andrew’s Choice bulb (674 µg Gal/g) and basal plate (1051 µg Gal/g). Non-dormant Carlton bulb was used as control, which represented the galanthamine content of 1117 µg Gal/g. Besides galanthamine, other biologically important alkaloids were detected in Carlton such as lycoramine, lycorine, lycorenine, crinamine, and pancracine; while tazettine, oxoassoanine, lycorine, and <em>o</em>-methyl-macronine were detected in Andrew’s Choice. Findings of this study suggest that both <em>Narcissus</em> cultivars could be the important sources for the isolation of naturally occurring bioactive alkaloids for their commercial availability and could be potentially used in pharmaceuticals.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2022-08-13 01:04:42
 
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Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 13, ##issue.no## 2 (2022): June 2022
 
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