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<p style="text-align: justify;">Protective efficacy of <em>Murraya koenigii</em> aqueous extract against monosodium glutamate-induced hepatotoxicity in Wistar rats</p>

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Title Statement <p style="text-align: justify;">Protective efficacy of <em>Murraya koenigii</em> aqueous extract against monosodium glutamate-induced hepatotoxicity in Wistar rats</p>
 
Added Entry - Uncontrolled Name Shinde, Madhuri ; Department of Pharmacology, MVG’s Pharmacy College, Panchavati, Nashik 4220003, Maharashtra, India
Mohan, Mahalaxmi ; Department of Pharmacology, MVG’s Pharmacy College, Panchavati, Nashik 4220003, Maharashtra, India
 
Uncontrolled Index Term preclinical toxicity
Hepatotoxicity; Monosodium glutamate; Murraya koenigii; Oxidative stress.
 
Summary, etc. <p style="text-align: justify;">The present work was designed to study the potential effect of antioxidant rich aqueous extract of <em>Murraya koenigii</em> (AE-MK) on monosodium glutamate-induced hepatotoxicity in Wistar rats. The study was conducted on thirty adult Wistar rats, classified into six groups. MSG (1000 mg/kg, p.o) was administered to induce hepatotoxicity. The MSG treated group showed significant (<em>P </em>˂0.05) increase in % change in body weight, relative organ weight, SOD, MDA, cholesterol, bilirubin, triglycerides, LDL levels; and AST, ALT activity while significant (<em>P</em> &lt;0.05) decrease in glutathione peroxidase, albumin, HDL level and ALP activity in liver tissue as compared to control group.<strong> </strong>AE-MK (200, 400 mg/kg) significantly (<em>P</em> &lt;0.05) reversed all the above parameters as compared to MSG treated rats.<strong> </strong>Histopathological changes observed in MSG treated rat liver tissue were cytoplasmic vacuolation, sinusoidal congestion, and cellular aggregates around the portal area. These changes were reversed with AE-MK (200, 400 mg/kg).<strong> </strong>The total phenol content was found to be 62 µg of gallic acid equivalent /mg of extract and free radical scavenging activity by DPPH method was found to be 74.16%. The study suggests that antioxidant rich aqueous extract of <em>M. koenigii</em> has protective effect against MSG-induced hepatotoxicity.<strong></strong></p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2022-08-13 01:04:42
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/48407
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 13, ##issue.no## 2 (2022): June 2022
 
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