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<p style="text-align: justify;">Phytochemical screening and antifungal activity <em>in vitro</em> of <em>Trichilia hirta</em> L. fruit extracts against clinical isolates of <em>Candida</em> spp.</p>

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Title Statement <p style="text-align: justify;">Phytochemical screening and antifungal activity <em>in vitro</em> of <em>Trichilia hirta</em> L. fruit extracts against clinical isolates of <em>Candida</em> spp.</p>
 
Added Entry - Uncontrolled Name Sierra, Jesus David ; Laboratorio Química de los Productos Naturales, Universidad de Córdoba. Carrera 6 No. 77-305 Montería, Córdoba, Postal code 230002, Colombia
Contreras, Orfa Ines ; Laboratorio Química de los Productos Naturales, Universidad de Córdoba. Carrera 6 No. 77-305 Montería, Córdoba, Postal code 230002, Colombia
Angulo, Alberto Antonio; Laboratorio Química de los Productos Naturales, Universidad de Córdoba. Carrera 6 No. 77-305 Montería, Córdoba, Postal code 230002, Colombia
 
Uncontrolled Index Term Antifungal activity; Candida spp.; Secondary metabolites; Trichilia hirta.
 
Summary, etc. <p style="text-align: justify;">The increase in resistance to antimicrobials is a public health problem worldwide; it puts at risk the prevention and effective treatment of multiple infections and is responsible for high rates of mortality and morbidity in hospitalized patients. Species of the genus <em>Candida</em> are among the main opportunistic pathogens isolated from hospitalized patients. The aim was to evaluate the antifungal activity of extracts obtained from <em>Trichilia hirta</em> fruits against clinical isolates of <em>Candida</em> spp. Extracts were obtained by Soxhlet and cold maceration methods using <em>T. hirta</em> fruits. Preliminary phytochemical screening was carried out to identify the presence of secondary metabolites. Antifungal activity of ethanol and petroleum benzene extracts of <em>T. hirta</em> was evaluated using microdilution and agar well diffusion methods. Kruskal-Wallis test was performed, with the application of contrast tests. The extracts showed secondary metabolites such as alkaloids, flavonoids, phenols, tannins and saponins, steroids and/or triterpenoids. Seed extract in petroleum ether and ethanol inhibited the growth of the clinical isolates of <em>Candida</em> spp., and the strain C. <em>albicans</em> ATCC 10231 in all concentrations. Ethanolic seed extract had an inhibitory effect on the largest number of isolates studied, generating maximum inhibition in <em>C. albicans</em>, <em>C. glabrata</em>, <em>C. parapsilosis</em>, and strain <em>C. albicans</em> ATCC 10231. Seed extract in petroleum ether showed the highest growth inhibition of <em>C. tropicalis</em>, <em>C. haemulonii</em>, and <em>C. krusei</em>. Extracts of <em>T. hirta</em> may be a promising source of antifungal compounds with the potential to be used in future research and the pharmacological industry.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2022-08-13 01:04:42
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/43786
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 13, ##issue.no## 2 (2022): June 2022
 
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