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Disease modifying activity of methanolic extract of Colchicum luteum against experimental gout in broiler chicken

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Title Disease modifying activity of methanolic extract of Colchicum luteum against experimental gout in broiler chicken
 
Creator Ali, Rayeesa
Kamil, S A
Mir, M S
Shah, S A
Wani, B M
Adil, S
Shafi, M
 
Subject Biochemical analysis
Colchicum luteum
Gout
Haematology
Sodium bicarbonate
 
Description 223-229
Colchicum luteum, a Himalayan herb has been found associated with immense pharmaceutical properties. The present
study was aimed to study the protective effect of methanolic extract of C. luteum against the haemato-biochemical
alterations due to sodium bicarbonate induced gout in broiler chicken. A total of 72 day old broiler chicks of average body
weights 178±20.8 g were divided into 6 groups (I to VI, n=12). Group I served as vehicle-treated control and was given
drinking water by oral gavage. Group II and III were given sodium bicarbonate @ 2.5 and 5% respectively in drinking
water. Group IV and V were provided with 2.5 and 5% sodium bicarbonate along with C. luteum extract @ 50 mg/kg body
weight respectively. Group VI served as treatment control and was given C. luteum extract @ 50 mg/kg body weight alone.
Haematological and biochemical analysis revealed a significant increase in haematological parameters (Hb, PCV, TEC,
TLC, and heterophil) and biochemical parameters (AST, ALT, uric acid, BUN, creatinine, total protein and albumin)
in sodium bicarbonate intoxicated groups. All these parameters however, were comparatively reduced in the birds given
C. luteum extract. Also, heterophil and monocyte counts were decreased significantly in group VI birds, supplemented with
C. luteum extract only with no adverse effect on health of birds. The results from the present study establish the protective
role of C. luteum extract against sodium bicarbonate induced haematological and biochemical alterations.
 
Date 2022-08-11T05:43:31Z
2022-08-11T05:43:31Z
2022-06
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/60262
https://doi.org/10.56042/ijnpr.v13i2.41191
 
Language en
 
Relation Int. cl. (2021.01)- A61K 36/00, A61K 36/896
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.13(2) [June 2022]