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Effect of the leaf and seed extract of Moringa peregrina (Forssk.) Fiori. in alloxan induced diabetic Mice

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Title Effect of the leaf and seed extract of Moringa peregrina (Forssk.) Fiori. in alloxan induced diabetic Mice
 
Creator Reddy, Salla Hemadri
Hatmi, Mizna Salim Ali Al
Kalbani, Alshima Rashid Al
 
Subject Alloxan
Antihyperglycaemic
Blood glucose
Body weight
Diabetes
Hypoglycaemic
Moringa peregrina
 
Description 183-187
Moringa peregrina (Forssk.) Fiori. is a well known medicinal plant used widely in the Sultanate of Oman for the treatment
of various disorders and diseases. In the present study, the antidiabetic potential with relevance to net weight change was carried
out using leaf and seed extracts. The experiment was carried out in alloxan (150 mg/kg body weight) induced diabetic mice by
oral administration (1.5 g/kg body weight) of M. peregrina seed and leaf extracts for 21 days. Pre and post treatment sugar
levels and body weight were monitored and evaluated. The results of antidiabetic activity of the extracts exhibited a significant
effect on reducing the blood glucose level in diabetic mice and showed very low effect on the mice body weight. Among the
tested extracts against diabetes in mice, the seed extract showed a significant reduction of blood sugar (-101.4 mg/dL; P ≤0.001)
followed by leaf extract (-83.7 mg/dL; P ≤0.001) without affecting body weight. These findings suggest that the hypoglycaemic
effect of M. Peregrina seed can be further studied to evaluate its mode and mechanism of action in the regulation of blood sugar
levels as well the chemical composition in the seed extracts need to be studied.
 
Date 2022-08-11T06:00:10Z
2022-08-11T06:00:10Z
2022-06
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/60267
https://doi.org/10.56042/ijnpr.v13i2.33499
 
Language en
 
Relation Int. cl. (2021.01)-A61K 36/00, A61K 127/00, A61K 131/00, A61P 3/00, A61P 3/10
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.13(2) [June 2022]