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Phytochemical screening and antifungal activity in vitro of Trichilia hirta L. fruit extracts against clinical isolates of Candida spp.

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Title Phytochemical screening and antifungal activity in vitro of Trichilia hirta L. fruit extracts against clinical isolates of Candida spp.
 
Creator Sierra, Jesus David
Contreras, Orfa Ines
Angulo, Alberto Antonio
 
Subject Antifungal activity
Candida spp
Secondary metabolites
Trichilia hirta
 
Description 170-175
The increase in resistance to antimicrobials is a public health problem worldwide; it puts at risk the prevention and effective
treatment of multiple infections and is responsible for high rates of mortality and morbidity in hospitalized patients. Species of the
genus Candida are among the main opportunistic pathogens isolated from hospitalized patients. The aim was to evaluate the
antifungal activity of extracts obtained from Trichilia hirta fruits against clinical isolates of Candida spp. Extracts were obtained by
Soxhlet and cold maceration methods using T. hirta fruits. Preliminary phytochemical screening was carried out to identify the
presence of secondary metabolites. Antifungal activity of ethanol and petroleum benzene extracts of T. hirta was evaluated using
microdilution and agar well diffusion methods. Kruskal-Wallis test was performed, with the application of contrast tests. The
extracts showed secondary metabolites such as alkaloids, flavonoids, phenols, tannins and saponins, steroids and/or triterpenoids.
Seed extract in petroleum ether and ethanol inhibited the growth of the clinical isolates of Candida spp., and the strain C. albicans
ATCC 10231 in all concentrations. Ethanolic seed extract had an inhibitory effect on the largest number of isolates studied,
generating maximum inhibition in C. albicans, C. glabrata, C. parapsilosis, and strain C. albicans ATCC 10231. Seed extract in
petroleum ether showed the highest growth inhibition of C. tropicalis, C. haemulonii, and C. krusei. Extracts of T. hirta may be a
promising source of antifungal compounds with the potential to be used in future research and the pharmacological industry.
 
Date 2022-08-11T06:05:24Z
2022-08-11T06:05:24Z
2022-06
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/60269
https://doi.org/10.56042/ijnpr.v13i2.43786
 
Language en
 
Relation Int. cl. (2021.01)- A61K 36/00, A61K 36/58, A61K 131/00, A61P 31/00
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.13(2) [June 2022]