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Biologically active Amaryllidaceae alkaloids in Narcissus pseudonarcissus cv. Carlton and Andrew’s Choice dormant bulbs

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Title Biologically active Amaryllidaceae alkaloids in Narcissus pseudonarcissus cv. Carlton and Andrew’s Choice dormant bulbs
 
Creator Das, Amit
Ferdausi, Aleya
Chang, Xianmin
Jones, Meriel
 
Subject Amaryllidaceae alkaloids
Galanthamine
Gas chromatography
Narcissus pseudonarcissus
Pharmaceuticals
 
Description 144-155
Since the ancient times, Amaryllidaceae genus Narcissus has been reported for the production of biologically important
alkaloids, many of which are used as therapeutic tools for human diseases. Among them, galanthamine (Gal) has received a
considerable attention for its acetylcholinesterase inhibitory activity for the treatment of early to mid-stage Alzheimer’s
diseases. In this study, gas chromatography-mass spectrophotometry was used to determine the galanthamine content along
with the detection of other biologically important alkaloids in dormant bulb and basal plate of two cultivated varieties of
Narcissus pseudonarcissus, Carlton and Andrew’s Choice. The amount of galanthamine was higher in Carlton bulb (860 μg
Gal/g) and basal plate (1254 μg Gal/g) than Andrew’s Choice bulb (674 μg Gal/g) and basal plate (1051 μg Gal/g). Nondormant
Carlton bulb was used as control, which represented the galanthamine content of 1117 μg Gal/g. Besides
galanthamine, other biologically important alkaloids were detected in Carlton such as lycoramine, lycorine, lycorenine,
crinamine, and pancracine; while tazettine, oxoassoanine, lycorine, and o-methyl-macronine were detected in Andrew’s
Choice. Findings of this study suggest that both Narcissus cultivars could be the important sources for the isolation of
naturally occurring bioactive alkaloids for their commercial availability and could be potentially used in pharmaceuticals.
 
Date 2022-08-11T06:16:08Z
2022-08-11T06:16:08Z
2022-06
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/60272
https://doi.org/10.56042/ijnpr.v13i2.51337
 
Language en
 
Relation Int. cl. (2021.01)-A61K 36/00, A61K 125/00
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.13(2) [June 2022]