Biologically active Amaryllidaceae alkaloids in Narcissus pseudonarcissus cv. Carlton and Andrew’s Choice dormant bulbs
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Title |
Biologically active Amaryllidaceae alkaloids in Narcissus pseudonarcissus cv. Carlton and Andrew’s Choice dormant bulbs
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Creator |
Das, Amit
Ferdausi, Aleya Chang, Xianmin Jones, Meriel |
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Subject |
Amaryllidaceae alkaloids
Galanthamine Gas chromatography Narcissus pseudonarcissus Pharmaceuticals |
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Description |
144-155
Since the ancient times, Amaryllidaceae genus Narcissus has been reported for the production of biologically important alkaloids, many of which are used as therapeutic tools for human diseases. Among them, galanthamine (Gal) has received a considerable attention for its acetylcholinesterase inhibitory activity for the treatment of early to mid-stage Alzheimer’s diseases. In this study, gas chromatography-mass spectrophotometry was used to determine the galanthamine content along with the detection of other biologically important alkaloids in dormant bulb and basal plate of two cultivated varieties of Narcissus pseudonarcissus, Carlton and Andrew’s Choice. The amount of galanthamine was higher in Carlton bulb (860 μg Gal/g) and basal plate (1254 μg Gal/g) than Andrew’s Choice bulb (674 μg Gal/g) and basal plate (1051 μg Gal/g). Nondormant Carlton bulb was used as control, which represented the galanthamine content of 1117 μg Gal/g. Besides galanthamine, other biologically important alkaloids were detected in Carlton such as lycoramine, lycorine, lycorenine, crinamine, and pancracine; while tazettine, oxoassoanine, lycorine, and o-methyl-macronine were detected in Andrew’s Choice. Findings of this study suggest that both Narcissus cultivars could be the important sources for the isolation of naturally occurring bioactive alkaloids for their commercial availability and could be potentially used in pharmaceuticals. |
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Date |
2022-08-11T06:16:08Z
2022-08-11T06:16:08Z 2022-06 |
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Type |
Article
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Identifier |
0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/60272 https://doi.org/10.56042/ijnpr.v13i2.51337 |
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Language |
en
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Relation |
Int. cl. (2021.01)-A61K 36/00, A61K 125/00
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Publisher |
NIScPR-CSIR,India
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Source |
IJNPR Vol.13(2) [June 2022]
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