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<p>Induction of antioxidant mechanisms in lung during experimental pancreatitis in rats</p>

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Title Statement <p>Induction of antioxidant mechanisms in lung during experimental pancreatitis in rats</p>
 
Added Entry - Uncontrolled Name Rechreche, Hocine
Abbes, Arbia
Iovanna, Juan Lucio
 
Uncontrolled Index Term ARDS, Caerulein, HSP-70, inflammation;Mn-SOD, mRNA expression
 
Summary, etc. Lung complications are the most common cause of death in patients with acute pancreatitis. In this study, we investigated how induction of mild acute pancreatitis could modify the course of lung inflammation, eventually, induced by a severe acute pancreatitis in rats. A severe and a mild forms of an experimental acute pancreatitis were respectively established by intra-ductal administration of sodium taurocholate to final dose of 50 mg/kg body wt. and intra-peritoneal injection of caerulein to supramaximal dose of 40 mg/kg body wt. We observed reduced levels of thiobarbiturate acid reacting substances when severe pancreatitis was preceded by the induction of mild pancreatitis. Moreover, mRNAs expression of both HSP-70 and Mn-SOD was increased in the lung. By contrast, the level of glutathione was reduced, but no change in the infiltration of neutrophils was observed. Therefore, we conclude that during the course of pancreatitis and its related lung inflammation, the pulmonary cells response involved in the expression of different protective proteins, including HSP-70 and Mn-SOD, which possibly improves the defensive mechanisms against inflammation in lung cells
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2020-05-01 00:00:00
 
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http://op.niscair.res.in/index.php/IJEB/article/view/65481
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 58, ##issue.no## 05 (2020): IJEB [MAY 2020]
 
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