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<p class="TitleMain"><em>Rauvolfia vomitoria </em>Afzel. disrupts dentate gyrus cells</p>

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Title Statement <p class="TitleMain"><em>Rauvolfia vomitoria </em>Afzel. disrupts dentate gyrus cells</p>
 
Added Entry - Uncontrolled Name Ekong, Moses B
Ekpene, Ubong U
Nwakanma, Agnes A
Eluwa, Mokutima A
Akpantah, Amabe O
 
Uncontrolled Index Term Immunoreactivity, The poison devil's-pepper
 
Summary, etc. <p class="Abstract" style="text-align: justify;">Herbal remedy for neurological problems may have adverse effects, and could prove detrimental if not regulated properly. <em>Rauvolfia vomitoria</em> (RV) is a herb commonly associated with psychiatry management because of its antipsychotic and sedative properties. Here, we studied the effects of the root bark extract of <em>R. vomitoria</em> on the dentate gyrus of adult Wistar rats. Twenty four adult Wistar rats (220 g average) were divided into four groups (n=6); control (placebo), 200, 300 and 400 mg/kg RV<em> </em>root bark extract, respectively for 7 days. The animals were sacrificed 24 h after last administration, and the brains were processed for histology and immunoreactivity.<em> </em>Results showed hypertrophy and atrophy of granule cells in all 200, 300 and 400 mg/kg RV groups, respectively. There was increased neuron specific enolase and glial fibrillary acidic protein expressions in the 200 and 300 mg/kg RV groups, while these proteins expression were decreased in the 400 mg/kg RV group. These results suggest that RV cause dentate gyrus cell injury in a dose-dependent pattern, and may lead to degeneration and disruption of functions.<strong></strong></p>
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2020-01-31 00:00:00
 
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http://op.niscair.res.in/index.php/IJEB/article/view/65345
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 58, ##issue.no## 02 (2020): IJEB [FEBRUARY 2020]
 
Language Note en