Record Details

Association of methylenetetrahydrofolate reductase C677T gene polymorphism and polycystic ovary syndrome in the South Indian cohort

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement Association of methylenetetrahydrofolate reductase C677T gene polymorphism and polycystic ovary syndrome in the South Indian cohort
 
Added Entry - Uncontrolled Name Sekar, Nishu
Samak, Radhika
Patil, Shreya
Ghorpade, Neha
Abilash, Valsala Gopalakrishnan
 
Uncontrolled Index Term Follicle-stimulating hormone, Luteinizing hormone, Metabolic syndromes, PCOS
 
Summary, etc. <p class="Abstract" style="text-align: justify;">The polycystic ovarian syndrome is the utmost common endocrinopathy state in women. It is related to both reproductive and metabolic disorders. The <em>MTHFR</em> gene associated with the ovarian follicular action encodes the 5-<em>MTHFR </em>(methylenetetra-hydrofolate reductase) enzyme, tangled in folate metabolism. <em>MTHFR</em> gene C677T polymorphism declines the enzyme activity and thus folate deficit and increases the level of homocysteine, which affects the progress of oocytes. Here, we evaluated the association of <em>MTHFR</em> gene C677T polymorphism withPolycystic ovary syndrome (PCOS) inthe South Indian cohortof women. About 129 PCOS women with following Rotterdam criteria and 90 women controls were studied. PCR-RFLP technique was carried out on all PCOS women in this study. Dissimilarities in hormone levels in PCOS patients were detected. <em>MTHFR </em>gene polymorphism CC, CT, TT genotype was found to be 74, 16, 9.30% in patients correspondingly. However, in controls, it was 44.4, 24, 31%, respectively. A substantial difference was detected in the genotype frequency distributions among the patients and controls. Also, allele frequency was shown as 82.95% C allele and 17.83% T allele and 56.67%, 43.33% for C, and T allele in controls correspondingly. Our resultsindicate a possible association and suggest that <em>MTHFR</em> C677T polymorphism can be used as a potential biomarker for PCOS progress in the South Indian women.</p>
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2020-07-01 00:00:00
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJEB/article/view/65597
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 58, ##issue.no## 07 (2020): IJEB [JULY 2020]
 
Language Note en