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<p><strong>Anti-tyrosinase, anti-elastase, and antioxidant activities of some symmetric bisthiocarbohydrazone compounds</strong></p>

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Title Statement <p><strong>Anti-tyrosinase, anti-elastase, and antioxidant activities of some symmetric bisthiocarbohydrazone compounds</strong></p>
 
Added Entry - Uncontrolled Name Kaya, Yeliz
Sacan, Ozlem
Erçağ, Ayşe
Yanardag, Refiye
 
Uncontrolled Index Term Thiocarbohydrazone; Isatin; Antityrosinase; Antielastase; Antioxidant
 
Summary, etc. <p>Symmetric bisthiocarbohydrazone compounds (1, 2, 3) were obtained by the condensation of thiocarbohydrazide with carbonyl compounds such as isatin (a heterocyclic ketone) and two hydroxyl aldehydes (2-hydroxybenzaldehyde, 2-hydroxy-1-naphthaldehyde) respectively, according to the previously reported methods. These synthesized compounds were evaluated in terms of their anti-tyrosinase, anti-elastase and antioxidant potentials in vitro. All of the tested compounds exhibited anti-tyrosinase and anti-elastase activities. It was observed that the inhibition increased with the increase of bisthiocarbohydrazone concentrations. Compound <strong>1</strong> showed the highest anti-tyrosinase activity. The anti-tyrosinase activity is decreasing in the following order;<strong> 2&lt;3&lt;1</strong>. Compound 1 showed also the highest anti-elastase activity. The anti-elastase activity is decreasing as <strong>3&lt;2&lt;1</strong>. As a result, the most effective compound in terms of anti-tyrosinase and anti-elastase activities is bisthiocarbohydrazone derived from isatin. Compounds <strong>2</strong> and <strong>3</strong> with the hydroxyl substitution showed antioxidant activity close to Trolox. These compounds were found to have significant reducing effects and to be effective scavengers of DPPH.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-08-16 12:31:01
 
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http://op.niscair.res.in/index.php/IJC/article/view/59458
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 8 (2022): Indian Journal of Chemistry - (IJC)
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJC/article/download/59458/465594615
http://op.niscair.res.in/index.php/IJC/article/download/59458/465594616