Record Details

<strong>SYNTHESIS, CHARACTERISATION AND EVALUATION OF SOME 1,5-BENZODIAZEPINE QUINOLIN-2-ONE DERIVATIVES AS POSSIBLE HYPNOTIC AGENTS.</strong>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <strong>SYNTHESIS, CHARACTERISATION AND EVALUATION OF SOME 1,5-BENZODIAZEPINE QUINOLIN-2-ONE DERIVATIVES AS POSSIBLE HYPNOTIC AGENTS.</strong>
 
Added Entry - Uncontrolled Name Raiturkar, Reema R; Departmentof Pharmaceutical Chemistry, P. E. S.’s Rajaram and TarabaiBandekar College of Pharmacy, Farmagudi, Ponda-Goa, 403401.
Desai, Shivalingrao N Mamle; Departmentof Pharmaceutical Chemistry, P. E. S.’s Rajaram and TarabaiBandekar College of Pharmacy, Farmagudi, Ponda-Goa, 403401.
Gracias, Vanessa M; Departmentof Pharmaceutical Chemistry, P. E. S.’s Rajaram and TarabaiBandekar College of Pharmacy, Farmagudi, Ponda-Goa, 403401.
Sangavkar, Aneka D Shenvi; Departmentof Pharmaceutical Chemistry, P. E. S.’s Rajaram and TarabaiBandekar College of Pharmacy, Farmagudi, Ponda-Goa, 403401.
Fernandes, Chrislyne ; Departmentof Pharmaceutical Chemistry, P. E. S.’s Rajaram and TarabaiBandekar College of Pharmacy, Farmagudi, Ponda-Goa, 403401.
Biradar, Bheemangouda S; Departmentof Pharmacology, P. E. S.’s Rajaram and TarabaiBandekar College of Pharmacy, Farmagudi, Ponda-Goa, 403401.
Chandavarkar, Sachin K; Department of Pharmacognosy, ASPM College of Pharmacy, Sangulwadi, Dist. Sindhudurg 416810.
 
Uncontrolled Index Term 1,5-Benzodiazepine, Docking, Hypnotic, Insomnia,Quinolin-2-one.
 
Summary, etc. A series of novel 3-(2-(phenyl/substituted phenyl)-1<em>H</em>-benzo[<em>b</em>] [1,5]-diazepin-4-yl)-4-methoxy-1-phenyl/methylquinolin-2(1<em>H</em>)-one <strong>[IV-a(1-6)/IV-b(1-6)]</strong> derivatives were synthesised by condensation of 3-substituted cinnamoyl-4-methoxy-1-phenyl/methylquinolin-2(1<em>H</em>)-one <strong>[III-a(1-6)/III-b(1-6)]</strong> with <em>o</em>-phenylenediamine. The results of the docking studies revealed that the synthesised compounds exhibited well conserved hydrogen bonding with one or more amino acid residues in the active pocket of alpha1beta3gamma2L GABA(A) Receptor (PDB ID: 6HUO) using Molegro Virtual Docker Software (MVD-2013, 6.0). The title compounds exhibited Mol Dock Score in the range of -124.502 to -149.448 with score more or comparable to the standard ligand score of -127.4127 and better than the standard drug -92.3878. All the synthesized compounds were satisfactorily characterized by spectral analysis and were tested for <em>in vivo </em>hypnotic activity based on the potentiation of barbiturate (phenobarbitone) sleeping time in miceusing diazepam as reference standard. All the compounds, except 4-methoxy-1-methyl-3-(2-(3-nitrophenyl)-1<em>H</em>-benzo[<em>b</em>][1,5]-diazepin-4-yl) quinolin-2(1<em>H</em>)-one <strong>(IV-b4)</strong>, significantly decreased the sleep latency, prolonged the duration of sleep and also showed good muscle relaxation property. Among the synthesised compounds, 4-methoxy-3-(2-(3-methoxyphenyl)-1<em>H</em>-benzo[<em>b</em>][1,5]-diazepin-4-yl)-1-phenylquinolin-2(1<em>H</em>)-one (<strong>I</strong><strong>V-a3</strong>) was found to be the most potenthypnotic agentwith sleep latency of 26.67 ± 2.629 min and sleeping time of 111.00 ± 6.028 minutesand matches with pharmacophore mapping of the designed molecule with the MolDock score.
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-08-16 12:31:01
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJC/article/view/65047
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 8 (2022): Indian Journal of Chemistry - (IJC)
 
Language Note en