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Anti-tyrosinase, anti-elastase, and antioxidant activities of some symmetric bisthiocarbohydrazone compounds

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Title Anti-tyrosinase, anti-elastase, and antioxidant activities of some symmetric bisthiocarbohydrazone compounds
 
Creator Kaya, Yeliz
Sacan, Ozlem
Erçağ, Ayşe
Yanardag, Refiye
 
Subject Thiocarbohydrazone
isatin
antityrosinase
antielastase
antioxidant
 
Description 895-900
Symmetric bisthiocarbohydrazone compounds (1, 2, 3) were obtained by the condensation of thiocarbohydrazide with
carbonyl compounds such as isatin (a heterocyclic ketone) and two hydroxyl aldehydes (2-hydroxybenzaldehyde, 2-hydroxy-1-
naphthaldehyde) respectively, according to the previously reported methods. These synthesized compounds were evaluated in
terms of their anti-tyrosinase, anti-elastase and antioxidant potentials in vitro. All of the tested compounds exhibited antityrosinase
and anti-elastase activities. It was observed that the inhibition increased with the increase of bisthiocarbohydrazone
concentrations. Compound 1 showed the highest anti-tyrosinase activity. The anti-tyrosinase activity is decreasing in the
following order; 2
 
Date 2022-08-16T08:33:00Z
2022-08-16T08:33:00Z
2022-08
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60294
https://doi.org/10.56042/ijc.v61i8.59458
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.61(08) [AUG 2022]