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Synthesis and antimicrobial activity of 2-((4-(1H-benzo[d]imidazol-2-yl)-6- (2-ethylcyclopentyl) pyrimidin-2-yl)thio)-N-methylacetamide

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Title Synthesis and antimicrobial activity of 2-((4-(1H-benzo[d]imidazol-2-yl)-6- (2-ethylcyclopentyl) pyrimidin-2-yl)thio)-N-methylacetamide
 
Creator Ch, Sunitha
G, Brahmeshwari
 
Subject Benzimidazole
pyrimidine
chloramphenicol
in vitro anti-bacterial activity
anti-fungal activity
 
Description 816-822
It has been possible to synthesise a brand new series of 2-((4-(1H-benzo[d]imidazol-2-yl)-6- (2-ethylcyclopentyl)pyrimidin-2-yl)thio)-N-methyl acetamide 4a-h. The reaction of 1-(1H-benzimidazol-2-yl)ethanone with 2-ethylcyclopentane carbaldehyde with ethanol and KOH yields (E)-1-(1H-benzo[d]imidazol-2-yl)-3- (2-ethylcyclopentyl)prop-2-en-1-one 1a-c. All compounds have been shown to have antimicrobial action via pharmacological study and are listed here. Chloramphenicol and Amphotericin B, two conventional antibiotics, have been compared to the antibacterial and antifungal properties of the synthetic compounds. It has been discovered that Schlenter products had spectroscopic properties worth investigating.
 
Date 2022-08-16T09:03:20Z
2022-08-16T09:03:20Z
2022-08
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/60303
https://doi.org/10.56042/ijc.v61i8.65055
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.61(08) [AUG 2022]