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Cardio protective activity of <em>Sargassum wightii</em> on isoproterenol induced myocardial stress in rats

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Title Statement Cardio protective activity of <em>Sargassum wightii</em> on isoproterenol induced myocardial stress in rats
 
Added Entry - Uncontrolled Name Renitta, R E
Rosario, S
Jane Cypriyana, P J
Samrot, A V
Dhiva, S
Abirami, S
Prakash, P
 
Uncontrolled Index Term Acute myocardial infarction, Cardioprotective activity, Isoproterenol, Marine algae, Sargassum wightii
 
Summary, etc. The aim of this investigation is to determine whether the methanolic extracts of <em>Sargassum wightii</em> can protect rats against isoproterenol-induced myocardial infarction. Four different groups of rats (6 rats in each group) were taken; where group 1 comprised of normal untreated rats, group 2 was injected with Isoproterenol (synthetic catecholamine), group 3 was considered as standard and hence, was injected with Isoproterenol + Simvastatin and group 4 was treated with Isoproterenol + <em>Sargassum wightii</em>’s<em> </em>extract. Cardioprotective effects of <em>Sargassum wightii </em>was observed via the changes in the lipid profile, cardio marker enzymes and through histopathological studies. Rats treated with the extract of <em>S</em>. <em>wightii</em> showed a significant reduction in total cholesterol, LDL-cholesterol, serum triglycerides and increase in HDL- cholesterol level indicating an undamaged myocardial membrane. Likewise, low enzyme activity in <em>Sargassum wightii </em>treated rats clearly indicated the cardioprotective effects of <em>Sargassum wightii. </em>Histopathological studies were also done to observe the changes on the rats at the tissue level and no pathological changes were observed in <em>Sargassum wightii </em>treated rats. Hence, methanolic extract of <em>Sargassum wightii </em>is evidenced to possess cardioprotective activity against myocardial infarction.
 
Publication, Distribution, Etc. Indian Journal of Geo-Marine Sciences (IJMS)
2022-08-24 01:32:42
 
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http://op.niscair.res.in/index.php/IJMS/article/view/65572
 
Data Source Entry Indian Journal of Geo-Marine Sciences (IJMS); ##issue.vol## 51, ##issue.no## 05 (2022)
 
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