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Antibacterial activity of the released metabolites of sea anemone Stichodactyla gigantea (Forskal, 1775) from the coast of South Andaman, India

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Title Antibacterial activity of the released metabolites of sea anemone Stichodactyla gigantea (Forskal, 1775) from the coast of South Andaman, India
 
Creator Heera, N S
Mishra, J K
Sneha, S
Sadaka, M C Shehin
 
Subject Antibacterial activity
Released Mucoid compound
South Andaman
Stichodactyla gigantea
 
Description 439-444
Marine sessile organisms produce unique bioactive metabolites, which render a defensive barrier against microbial threats and increase survivability in the middle of predators. The earlier studies focused on isolated metabolites from marine sources, composed to exhibit antibacterial, antiviral, and cytotoxic properties. The present study aims to evaluate the antibacterial property of the anemone-released metabolites. The crude and released mucoid metabolite obtained from the sea anemone Stichodactyla gigantea (Forskal, 1775) assayed against five human pathogens like Bacillus subtilis (MTCC 121), Listeria monocytogenes (MTCC 839), Staphylococcus aureus (MTCC839), Bacillus cereus (MTCC 443), and Salmonella enterica typhimurium (MTCC 1252). The assay exhibited positive activity against two pathogens, viz. B. subtilis (MTCC 121) and L. monocytogenes (MTCC 839). Based on the demonstrated activity, the released metabolites were purified using Open Column chromatography. The fractions collected were subjected to an antibacterial assay, which showed a high inhibition zone of 39 mm and 23 mm in diameter against B. subtilis and L. monocytogenes. Followingly, the characterization of purified fractions through GC-MS analysis confirmed the presence of 22 compounds. This study reveals the potential power of the released mucoid metabolites against antibiotic-resistive pathogens. Further studies are essential to elucidate the role of endosymbiont's contribution to mucoid production and their responsiveness towards tackling stressed conditions
 
Date 2022-08-22T11:39:36Z
2022-08-22T11:39:36Z
2022-05
 
Type Article
 
Identifier 2582-6727 (Online); 2582-6506 (Print)
http://nopr.niscpr.res.in/handle/123456789/60326
https://doi.org/10.56042/ijms.v51i05.65562
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJMS Vol.51(05) [May 2022]