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Cardio protective activity of Sargassum wightii on isoproterenol induced myocardial stress in rats

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Title Cardio protective activity of Sargassum wightii on isoproterenol induced myocardial stress in rats
 
Creator Renitta, R E
Rosario, S
Cypriyana, P J Jane
Samrot, A V
Dhiva, S
Abirami, S
Prakash, P
 
Subject Acute myocardial infarction
Cardioprotective activity
Isoproterenol
Marine algae
Sargassum wightii
 
Description 412-417
The aim of this investigation is to determine whether the methanolic extracts of Sargassum wightii can protect rats
against isoproterenol-induced myocardial infarction. Four different groups of rats (6 rats in each group) were taken; where
group 1 comprised of normal untreated rats, group 2 was injected with Isoproterenol (synthetic catecholamine), group 3 was
considered as standard and hence, was injected with Isoproterenol + Simvastatin and group 4 was treated with Isoproterenol
+ Sargassum wightii’s extract. Cardioprotective effects of Sargassum wightii was observed via the changes in the lipid
profile, cardio marker enzymes and through histopathological studies. Rats treated with the extract of S. wightii showed a
significant reduction in total cholesterol, LDL-cholesterol, serum triglycerides and increase in HDL- cholesterol level
indicating an undamaged myocardial membrane. Likewise, low enzyme activity in Sargassum wightii treated rats clearly
indicated the cardioprotective effects of Sargassum wightii. Histopathological studies were also done to observe the changes
on the rats at the tissue level and no pathological changes were observed in Sargassum wightii treated rats. Hence,
methanolic extract of Sargassum wightii is evidenced to possess cardioprotective activity against myocardial infarction.
 
Date 2022-08-22T11:51:09Z
2022-08-22T11:51:09Z
2022-05
 
Type Article
 
Identifier 2582-6727 (Online); 2582-6506 (Print)
http://nopr.niscpr.res.in/handle/123456789/60330
https://doi.org/10.56042/ijms.v51i05.65572
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJMS Vol.51(05) [May 2022]