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In-silico analysis of bioactive compounds extracted from seaweed Amphiroa anceps on the pathogenicity of bacteria

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Title In-silico analysis of bioactive compounds extracted from seaweed Amphiroa anceps on the pathogenicity of bacteria
 
Creator Madathil, D
Chidambaram, R
 
Subject Amphiroa anceps
Antibacterial activity
Docking
Pathogens
Phytocompounds
 
Description 379-387
Screening of biochemical compounds in marine algae is a gateway to understand the bioactive principles of antimicrobial
activity and may be a significant tool in developing environment friendly herbicides and in drug discovery. In this study, the
antibacterial activity of the seaweed Amphiroa anceps extracted with methanol and ethanol was determined against clinical
isolates namely Vibrio cholerae 01 ogawa, Vibrio cholerae O139, Vibrio fluvialis, Vibrio parahaemolyticus,
V. parahaemolyticus 81, V. parahaemolyticus O3:K6, salmonella enteritidis type 5, Enterotoxigenic E. coli, Bacillus cereus
by disc diffusion method at different concentrations. Ethanolic extract showed the highest activity against
V. parahaemolyticus, V. parahaemolyticus 81 and V. cholerae. The FTIR results showed the presence of major functional
groups like amine, hydrogen bonded alcohols, alkanes and aromatic rings. Four major bioactive compounds were selected
based on GC-MS data and used as ligands to dock in-silico against proteins of pathogenic bacteria that were used in
antibiotic studies.
 
Date 2022-08-22T12:02:01Z
2022-08-22T12:02:01Z
2022-05
 
Type Article
 
Identifier 2582-6727 (Online); 2582-6506 (Print)
http://nopr.niscpr.res.in/handle/123456789/60334
https://doi.org/10.56042/ijms.v51i05.65560
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJMS Vol.51(05) [May 2022]