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In silico interaction of Berberine with some immunomodulatory targets: A docking analysis

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Title In silico interaction of Berberine with some immunomodulatory targets: A docking analysis
 
Creator Ganeshpurkar, Aditya
Chaturvedi, Aman
Shrivastava, Abhishek
Dubey, Nazneen
Jain, Swati
Saxena, Nischal
Gupta, Pratik
Mujariya, Rajesh
 
Subject Berberine
Cytokines
Immunomodulatory
Inflammation
Nitric oxide
 
Description 848-853
Plant, mineral, and animal products have been utilized as
medications from the beginning of time to cure a variety of
ailments. Use of medicinal herbs to modulate immune function
has a rich history. Natural products serve as the foundation for
contemporary pharmaceutical ingredients. Immunomodulation
alters an individual's immune system by interfering with its
normal processes. Immunomodulators derived from natural
sources have been extensively studied in order to modify the
immune system and prevent illness. Berberine is an alkaloid has
been identified for its anti-inflammatory properties. In animal
studies, Berberine was found to demonstrate analgesic properties.
The current work is aimed to explore the in silico interactions of
Berberine with various chemokines and inflammatory pathways.
Berberine was docked with TNF-α, IL-1β, IL-6, and NOs in this
investigation. Docking study demonstrated notable interactions
with these targets. The present research provides insight into the
development of new compounds for immunomodulation and the
management of inflammatory illnesses. More research on
Berberine and related flavonoids is necessary to assess its safety.
As a result, Berberine can be regarded as a candidate for the
advancement of an immunomodulatory agent.
 
Date 2022-08-23T11:09:34Z
2022-08-23T11:09:34Z
2022-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/60339
https://doi.org/10.56042/ijbb.v59i8.62908
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJBB Vol.59(8) [AUGUST 2022]