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Computational studies on new Leishmanial drug targets against Quercetin

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Title Computational studies on new Leishmanial drug targets against Quercetin
 
Creator Jyothi, Kanagaraj
Sivaranjani, V
Pavithra, U
Jayavel, Sridhar
Muthulakshmi, Lakshmanan
 
Subject Anti-leishmanial drug
Leishmaniasis
Quercetin
 
Description 909-917
Leishmaniasis, a parasitic disease caused by Leishmania parasite which resides in the infected sand flies. Control of Leishmaniasis remains a source of grave concern worldwide. Studies on Leishmaniasis triggered because of its outbreak in tropical and subtropical regions of Asia, East Africa and South America. There is an urgent need for new therapeutic interventions such as vaccine and new drug targets as it develops resistance towards the available drugs. Quercetin, a derivative of polyphenolic flavonoid exhibits various biological activities by interacting with proteins and nucleic acids. In this study, computational analysis was performed to identify the potential drug target of Quercetin in Leishmania species by molecular docking. The newly predicted targets were subjected for subcellular localization prediction and determined the protein-protein interaction networks that would aid in the development of anti-Leishmanial drugs. This study helps in the identification of targets and development of anti-Leishmanial drugs.
 
Date 2022-08-30T09:08:25Z
2022-08-30T09:08:25Z
2022-09
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/60403
https://doi.org/10.56042/ijbb.v59i9.61006
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.59(9) [SEP 2022]