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Potential anticancer peptides design from the cysteine rich plant defensins: An in silico approach

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Title Potential anticancer peptides design from the cysteine rich plant defensins: An in silico approach
 
Creator Shafique, Mohd
Sarma, Siddhartha P
 
Subject Anticancer peptides
Cancer
Interferon-gamma induction
Peptides
Plant defensins
 
Description 900-908
Cancer is the second leading cause of mortality worldwide preceded by cardiovascular diseases. The therapeutic approaches
for drug developmentinclude the use of small molecules, antibodies, peptidesor short nucleic acid sequences. The peptide-based
drugs have been developed to treat many diseases like cardiovascular diseases, cancer, metabolic disorders, immunological
diseases and viral infections. More than 80 peptide drugs are already in the market. These therapeutic peptides have several
important benefits over antibodies and proteins due to their small size, ease for chemical synthesis and further the ability to
penetrate cell membrane. Furthermore, peptide drugs have high specificity, activity, and affinity. The plant defensins BcDef1,
TPP3, NaD1, 2N2R and 2LR3 have been studied for their role in wide range of diseases. This study focussed on the
conformation of plant defensins rich in disulfide bonds. The structure for BcDef1 has been predicted from the conformational
ensemble. Then, we designed anticancer peptides from these defensins with computational methods. The designed anticancer
peptides have been studied for their immunogenicity as well as homology with human proteome. The role of designed peptides
has been suggested for interferon-gamma induction, the later has been shown to possess a very important role in cancer.
 
Date 2022-08-30T09:11:19Z
2022-08-30T09:11:19Z
2022-09
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/60404
https://doi.org/10.56042/ijbb.v59i9.60883
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.59(9) [SEP 2022]