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The role of lipids and fatty acid metabolism in the development of prostate cancer

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Title The role of lipids and fatty acid metabolism in the development of prostate cancer
 
Creator Kotrikadze, Nanuli
Alibegashvili, Manana
Ramishvili, Liana
Mikaia, Nino
Khazaradze, Ana
Sepiashvili, Bela
Nakashidze, Irina
Gordeziani, Manana
Ahmad, Sarfraz
 
Subject Analytical assessments
De novo synthesis
Free fatty acids
Lipids
Metabolism
Peroxidation
Phospholipids
Prostate cancer
 
Description 873-878
The reprogramming of lipid metabolism and signaling pathways is the central aspect of cancer biology. It is hypothesized
that tumor cells can alter the lipid spectrum in order to fulfill their metabolic requirements. Furthermore, they can alter
potential tumors and suppressive mechanisms in which lipids' involvement is essential. Recently, more attentions have been
given on the alteration of lipid metabolism during prostate cancer development, and investigations have shown unique
regulation of "de novo" lipid synthesis in cancer cells. Cancer cells often use newer pathways and enzymes to simplify the
synthesis of fatty acids, and the newly synthesized lipids affect cellular processes, which impacts cancer cell proliferation
and survival outcomes. Herein, we aimed to study the influence of lipid profile alterations on the development of prostate
cancer. We found that the total amounts of lipids and phospholipids were increased within tissues from men with the
malignant prostate tumor as compared with the benign prostate tissue. Significant changes were also observed in the
composition of saturated and unsaturated fatty acids within the malignant tumor tissues. Intensification of lipid peroxidation
has also been observed in malignant prostate tumors compared to benign prostate tumors. Collectively, these findings further
highlights the fact that lipid and fatty acids play unique regulatory roles in the cellular development of prostate malignant
transformation.
 
Date 2022-08-30T09:21:31Z
2022-08-30T09:21:31Z
2022-09
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/60407
https://doi.org/10.56042/ijbb.v59i9.65614
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.59(9) [SEP 2022]