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A review on phyto-nanotechnology for therapy of alzheimer’s disease

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Title A review on phyto-nanotechnology for therapy of alzheimer’s disease
 
Creator Rajamanickam, Gayathri
SL, Manju
 
Subject Amyloid plaque
Blood-brain barrier
CNS
Nanotechnology
Natural products
 
Description 867-872
Alzheimer’s disease (AD) is a common chronic neurodegenerative disease (ND) that is mainly investigated nowadays
because of its increased incidence and burden on the elderly population. It leads to atrophy of the brain. Clinical features of
AD include loss of memory with impaired cognition and behaviour, which leads to mood instability and death. Aggregation
of beta-amyloid protein(Aβ) and neurofibrillary tangles within the neuronal cells are the accepted pathophysiological
process of AD. Studies have demonstrated that medicinal plants and herbs could improve memory and cognitive function
affected by AD. The bioavailability of active herbal components is affected by rapid metabolism, less permeability, and
decreased stability within the CNS. Many studies have reported that the application of nanotechnology to plant extracts
enhances the efficacy of extracts. Adding herbal extracts into the nanoparticle system could improve the action of extracts,
promote the sustained release of bioactive components, decrease the required dose, and lower the side effects. Using
published articles from trustworthy resources like PubMed, Google Scholar, Research Gate, Web of Science, and Wiley
Online Library, with keywords like "natural products," "Alzheimer's disease," and "nanotechnology," herein we reviewed
and summarized recent nano-drug delivery treatment strategies for AD using natural products.
 
Date 2022-08-30T09:23:37Z
2022-08-30T09:23:37Z
2022-09
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/60408
https://doi.org/10.56042/ijbb.v59i9.57758
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.59(9) [SEP 2022]