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Kinetics and in vitro release studies of drug loaded silver nanoparticles from Indigofera tinctoria extract

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Title Kinetics and in vitro release studies of drug loaded silver nanoparticles from Indigofera tinctoria extract
 
Creator Khambhaty, Yasmin
Bondada, Suryakiran
Mandal, Sujata
 
Subject Biological activity
Drug release
Indigofera tinctoria
Kinetics
Silver nanoparticles
 
Description 473-484
Silver nanoparticles (AgNP’s) have been successfully fabricated via bio-reduction of Indigofera tinctoria plant extract
as the reducing and capping agent. The effects of pH and temperature on the formation of the AgNP’s have been studied.
The synthesized AgNP’s have been characterized using UV-Visible spectroscopy, Fourier Transform Infrared (FTIR)
spectroscopy, Zeta potential analysis, Scanning Electron Microscope (SEM) and Atomic Force Microscopy (AFM).
Antimicrobial activities of the synthesized AgNP’s have been tested against both bacterial and fungal strains by agar well
diffusion method. The biomass-capped AgNP’s imparted antimicrobial activity by inhibiting the growth of Escherichia coli,
Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus, Aspergillus niger and Penicillium chrysogenum. The
antioxidant activities of the synthesized AgNP’s exhibit low IC50 value of ~55.72 μg/mL. Studies on drug loading and
kinetics of drug release reveal that I. tinctoria AgNP’s follow the zero-order kinetics at pH 4.6 and pH 7.4. The gradient
value of 0.568 (pH 4.6) and 0.6 (pH 7.4) falls between 0.42 < n < 0.85 when fitted into Peppa’s plot indicating that the drug
release follow an anomalous transport or non-Fickian diffusion transport, indicating that the diffusion is time dependent.
 
Date 2022-08-31T08:21:29Z
2022-08-31T08:21:29Z
2022-09
 
Type Article
 
Identifier 0975-0991 (Online); 0971-457X (Print)
http://nopr.niscpr.res.in/handle/123456789/60435
https://doi.org/10.56042/ijct.v29i5.62741
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJCT Vol.29(5) [September 2022]