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Assessment of genotoxicity induced by helminthes parasites in freshwater fishes of river Ganges

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Title Assessment of genotoxicity induced by helminthes parasites in freshwater fishes of river Ganges
 
Creator Jaiswal, Neeshma
Srivastava, Rashmi
Srivastava, Rakesh
Mishra, Suman
Jaiswal, Kamal
Malhotra, Sandeep
 
Subject Comet assay
Host-parasite interaction
Micro Nucleus Test
Tissue specificity
 
Description 719-726
Several parasites have been shown to induce genotoxicity in humans and fish are important intermediate hosts for
completing the life cycle of many parasites, posing a huge economic loss worldwide through the ecosystem food chain. In
the present study, we assessed the genotoxic potential of helminth Rostellascaris sp. through a benchmark of comet assay
and micronucleus (MNi) tests on the hepatocytes, muscle, and whole blood of infected fish Bagarius bagarius (Hamilton)
collected from different sites of the river Ganges. The percentage of the mean tail length of the comet was 10.28±0.36 in the
reticulocytes of the infected fish which was significantly (P ˂0.05) longer compared to the control (2.86±0.12). Similarly, a
significantly (P ˂0.05) higher DNA damage was observed in hepatocytes of parasite-infected fish (12.15±0.24) when
compared to the control (3.024±0.013). A comparatively higher DNA damage was observed in the hepatocytes than the
reticulocytes, indicative of tissue-specific DNA damage as hepatocytes are the biomarkers of metabolic functions prone
toward biotic stress. A higher induction of MN was observed in infested fish (0.18±0.07) as compared to the control. Our
results suggest that parasites contribute to the induction of cellular and DNA damage in fish during the progression of the
host-parasite interaction.
 
Date 2022-09-01T06:08:45Z
2022-09-01T06:08:45Z
2022-09
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/60440
https://doi.org/10.56042/ijeb.v60i09.65148
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJEB Vol.60(09) [Sep 2022]