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HPLC/QTOF-MS metabolomics analysis applied to identify skin biomarkers of UVC-induced skin injury in mice and preventive effects of abietic acid

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Title Statement HPLC/QTOF-MS metabolomics analysis applied to identify skin biomarkers of UVC-induced skin injury in mice and preventive effects of abietic acid
 
Added Entry - Uncontrolled Name Yang, Nianyun ; Nanjing University of Chinese Medicine
Qian, Jiaojiao
Tian, Lijuan
 
Uncontrolled Index Term Adenosine; Ceramides; dCMP; Pine resin; Pinus massoniana
 
Summary, etc. Abietic acid (AA) is a main constituent from pine resin, which has definite therapeutical effects for treating skin ulcers and tumor. Here, we explored the metabolome changes in skin tissues of mice with UVC-induced skin injury treated with AA by a HPLC-QTOF-MS/MS method. Model mice were induced with UVC irradiation. Skin histopathological changes were examined by routine HE staining. Metabolomic analysis technology and pattern recognition statistical method were applied to analyze the metabolites in the skin tissues of mice to study the therapeutic effect of AA on UVC-induced skin injury in mice. Ceramides, sphingosines, glycyl-L-glutamine, dihydroorotic acid, adenosine, dCMP and lyso-phosphatidylcholines can be used as biomarkers of UVC-induced skin injury. AA can improve the pathological tissue from the pathway of skin lipid and purine pyrimidine metabolism to achieve the therapeutic effect. AA can effectively treat UVC-induced skin injury in mice.
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2022-09-01 00:00:00
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJEB/article/view/41848
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 60, ##issue.no## 09 (2022): IJEB [SEPTEMBER 2022]
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJEB/article/download/41848/465532101