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Evaluation of <em>in vivo </em>antidiabetic activity of <em>Notonia grandiflora</em> Wall.

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Title Statement Evaluation of <em>in vivo </em>antidiabetic activity of <em>Notonia grandiflora</em> Wall.
 
Added Entry - Uncontrolled Name Paul, Meera ; Mookambika College of Pharmaceutical Sciences and Research, Muvattupuzha, Kerala 686667, India
Sanilkumar, R ; Department of Pharmacy, Annamalai University, Annamalai Nagar 608002, Tamil Nadu, India
M C, Sabu ; Mookambika College of Pharmaceutical Sciences and Research, Muvattupuzha, Kerala 686667, India
 
Uncontrolled Index Term Pharmacology
Antidiabetic activity; Ethyl acetate extract; In vivo; Notonia grandiflora; Streptozotocin.
 
Summary, etc. <p style="text-align: justify;">The aim of this study was to determine the <em>in vivo </em>hypoglycaemic activity of ethyl acetate extract of <em>Notonia grandiflora </em>(EANG) in albino wistar rats. EANG was orally administrated to STZ (40 mg/kg, i.p, b.w) induced diabetic rats at the doses of 100 and 200 mg/kg b.w for 21 days. The effect of EANG on blood glucose, body weight, plasma insulin, urea, uric acid, creatinine, Hb, HbA1C, liver glycogen content, bilirubin level, liver enzymes (Serum glutamate pyruvate transaminases, serum glutamate oxaloacetate transaminases, alkaline phosphatase) were measured in the diabetic rats. Treatment of EANG significantly lowered the levels of blood glucose and glycosylated haemoglobin. It also restored body weight, liver glycogen content, and serum insulin level in diabetic rats in a dose-dependent manner. A significant reduction in the activity of liver function enzymes associated with diabetes and serum levels of renal parameters after treatment with EANG was observed, signifying the protective effects of EANG in diabetes-associated complications. Hence, it could be used as a safer complementary drug in the management of diabetes and associated complications.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2022-09-06 11:30:19
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/52630
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 13, ##issue.no## 3 (2022): September 2022 (Ahead of Print)
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJNPR/article/download/52630/465570721
 
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