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<p style="text-align: justify;">Antioxidant, anti-inflammatory, thrombolytic, and cytotoxic activities of <em>Gynura nepalensis </em>DC. and isolation of its steroid constituents</p>

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Title Statement <p style="text-align: justify;">Antioxidant, anti-inflammatory, thrombolytic, and cytotoxic activities of <em>Gynura nepalensis </em>DC. and isolation of its steroid constituents</p>
 
Added Entry - Uncontrolled Name Bari, Md. Sazzadul ; Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhaka 1205, Bangladesh
Das, Amit Chandra; Department of Clinical Pharmacy & Pharmacology, University of Dhaka, Dhaka 1000, Bangladesh
Bhuiyan, Md. Mohi Uddin; Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhaka 1205, Bangladesh
Khatun, Sonia ; Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhaka 1205, Bangladesh
Mitu, Anjumanara ; Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhaka 1205, Bangladesh
Khandokar, Labony ; Department of Pharmacy, East West University, A/2 Jahurul Islam Ave, Dhaka 1212, Bangladesh
 
Uncontrolled Index Term Natural product chemistry; Structure elucidation; Biological activity
Anti-inflammatory; Antioxidant; Cytotoxic; Gynura nepalensis; Sterols; Thrombolytic.
 
Summary, etc. <p style="text-align: justify;">The study was aimed at phytochemical profiling of <em>Gynura nepalensis</em> DC. as well as assessment of possible antioxidant, anti-inflammatory, thrombolytic, and cytotoxic activities of its fractions named hexane (HSF), dichloromethane (DCMSF), ethyl acetate (EASF) and aqueous (AQSF) soluble fractions through <em>in vitro </em>assays. Chromatographic fractionation and purification followed by <sup>1</sup>H NMR spectral analysis afforded two sterols named β-sitosterol and stigmasterol, which appears to be a first-time reporting from the species. In the free radical scavenging assay, both DCMSF and EASF exhibited prominent antioxidant activities which was further reinforced by their comparatively greater phenolic content. In membrane stabilizing test, prominent inhibitions of hemolysis as exerted by EASF, AQSF, and DCMSF, were evident of their significant anti-inflammatory activities, compared to aspirin. With respect to streptokinase, HSF and DCMSF demonstrated moderate thrombolytic properties, whereas in the cytotoxicity study, only HSF illustrated prominent cytotoxic properties. In conclusion, the results are suggestive of the presence of bioactive molecules within the fractions capable of exerting potent pharmacological activities.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2022-09-06 11:30:19
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/37833
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 13, ##issue.no## 3 (2022): September 2022 (Ahead of Print)
 
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